Detailed information of TA system TA144037

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1660012..1660711
• Replicon: chromosome
• Accession: NZ_CP046341
• Organism: Burkholderia multivorans strain FDAARGOS_726

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: FOC34_RS07360
• Protein ID: WP_059786235.1
• Coordinates: 1660012..1660308 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: FOC34_RS07365
• Protein ID: WP_059786238.1
• Coordinates: 1660310..1660711 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC34_RS07345	1656731..1658275	+	1545	WP_170935331.1	sensor domain-containing diguanylate cyclase	-
FOC34_RS07350	1658483..1658755	+	273	WP_155817567.1	hypothetical protein	-
FOC34_RS07355	1658858..1659892	+	1035	WP_006397017.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
FOC34_RS07360	1660012..1660308	+	297	WP_059786235.1	type II toxin-antitoxin system MqsR family toxin	Toxin
FOC34_RS07365	1660310..1660711	+	402	WP_059786238.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
FOC34_RS07370	1660999..1661559	+	561	WP_155817569.1	GNAT family N-acetyltransferase	-
FOC34_RS07375	1661625..1662566	+	942	WP_039217954.1	ABC transporter substrate-binding protein	-
FOC34_RS07380	1662598..1663659	+	1062	WP_155817572.1	LLM class flavin-dependent oxidoreductase	-
FOC34_RS07385	1663656..1665008	+	1353	WP_006413139.1	LLM class flavin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11215.10 Da
• Isoelectric Point: 9.1122

>T144037 WP_059786235.1 NZ_CP046341:1660012-1660308 [Burkholderia multivorans]
MEKRTPHCKLPRVKALIEAGKVRLTASAVIGARQMGFTESETIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T144037 NZ_CP061666:c3649158-3648769 [Acinetobacter seifertii]
TTGATCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCGCGATTGTATTTCAGTTTTTTATTGGCCTATGTTTAGC
AGCTCTGTTTTATCAGCTGATACCAATACTCTGGTGGTTGGTTACGCTCTGTTTATTATTTATAAGTTTTATTTTCTTTT
TAAAGCGACCACAGCTCGTTCAAATTGCCTATTTAGATCAGAAATTATGGTCTCTTAGCTTTCATTCAGAACAAACCATT
TCTCGTGTAGAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGGTCTATTTTAAGGGTGATAAAACATTAACTTC
TGTTATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAACAGCTTAAGACTTTAGAAAAATTCTATTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14507.65 Da
• Isoelectric Point: 7.0834

>AT144037 WP_059786238.1 NZ_CP046341:1660310-1660711 [Burkholderia multivorans]
MKCPACGAATLVRDTRDIPYTYKGESTVIPHVTGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKLLDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT144037 NZ_CP061666:c3649410-3649165 [Acinetobacter seifertii]
ATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTTTGACCCGTATGT
GAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAGATCCTGATTTAC
TTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAGCATTATGTTCAT
GGCTGA