Detailed information of TA system TA144030

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 880236..880935
• Replicon: chromosome
• Accession: NZ_CP046337
• Organism: Burkholderia multivorans strain FDAARGOS_719

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: FOC27_RS20135
• Protein ID: WP_059786235.1
• Coordinates: 880236..880532 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: B9B077
• Locus tag: FOC27_RS20140
• Protein ID: WP_006397015.1
• Coordinates: 880534..880935 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC27_RS20120	876955..878499	+	1545	WP_170935331.1	sensor domain-containing diguanylate cyclase	-
FOC27_RS20125	878707..878979	+	273	WP_012216969.1	hypothetical protein	-
FOC27_RS20130	879082..880116	+	1035	WP_006397017.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
FOC27_RS20135	880236..880532	+	297	WP_059786235.1	type II toxin-antitoxin system MqsR family toxin	Toxin
FOC27_RS20140	880534..880935	+	402	WP_006397015.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
FOC27_RS20145	881221..881781	+	561	WP_155825035.1	GNAT family N-acetyltransferase	-
FOC27_RS20150	881847..882788	+	942	WP_155825036.1	ABC transporter substrate-binding protein	-
FOC27_RS20155	882819..883880	+	1062	WP_155825037.1	LLM class flavin-dependent oxidoreductase	-
FOC27_RS20160	883877..885229	+	1353	WP_155825038.1	LLM class flavin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (72-109)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11215.10 Da
• Isoelectric Point: 9.1122

>T144030 WP_059786235.1 NZ_CP046337:880236-880532 [Burkholderia multivorans]
MEKRTPHCKLPRVKALIEAGKVRLTASAVIGARQMGFTESETIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T144030 NZ_CP061647:83902-84258 [Acinetobacter seifertii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATGAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14477.62 Da
• Isoelectric Point: 7.0834

>AT144030 WP_006397015.1 NZ_CP046337:880534-880935 [Burkholderia multivorans]
MKCPACGAAALVRDTRDIPYTYKGESTVIPHVTGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKLLDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT144030 NZ_CP061647:84251-84553 [Acinetobacter seifertii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATAGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA

Structures

Antitoxin

• AlphaFold DB: B9B077