Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1644440..1645110 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name higB Uniprot ID O53332
Locus tag FOC58_RS07945 Protein ID WP_003899954.1
Coordinates 1644440..1644784 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0THF6
Locus tag FOC58_RS07950 Protein ID WP_003899955.1
Coordinates 1644781..1645110 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS07910 1639513..1640373 + 861 WP_003416628.1 alpha/beta hydrolase -
FOC58_RS07915 1640348..1640863 + 516 WP_003899950.1 nitroreductase family deazaflavin-dependent oxidoreductase -
FOC58_RS07925 1641103..1641396 + 294 WP_003416635.1 hypothetical protein -
FOC58_RS07930 1641684..1642973 + 1290 WP_003416640.1 ATP-binding protein -
FOC58_RS07935 1643320..1643754 - 435 WP_003899952.1 type II toxin-antitoxin system VapC family toxin -
FOC58_RS07940 1643757..1644209 - 453 WP_003899953.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FOC58_RS07945 1644440..1644784 + 345 WP_003899954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOC58_RS07950 1644781..1645110 + 330 WP_003899955.1 XRE family transcriptional regulator Antitoxin
FOC58_RS07955 1645235..1646496 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
FOC58_RS07960 1647006..1647353 + 348 WP_003899956.1 DUF2384 domain-containing protein -
FOC58_RS07965 1647350..1647970 + 621 WP_003899957.1 RES family NAD+ phosphorylase -
FOC58_RS07970 1648130..1649395 - 1266 WP_003902423.1 hypothetical protein -
FOC58_RS07975 1649563..1649772 + 210 WP_003416778.1 hypothetical protein -
FOC58_RS20915 1649807..1649992 + 186 WP_015630737.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12692.50 Da        Isoelectric Point: 5.6920

>T143967 WP_003899954.1 NZ_CP046309:1644440-1644784 [Mycobacterium tuberculosis]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Download         Length: 345 bp

>T143967 NZ_CP061527:3707248-3707355 [Shigella dysenteriae]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11802.46 Da        Isoelectric Point: 7.4051

>AT143967 WP_003899955.1 NZ_CP046309:1644781-1645110 [Mycobacterium tuberculosis]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA

Download         Length: 330 bp

>AT143967 NZ_CP061527:c3707200-3707134 [Shigella dysenteriae]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBK2

Antitoxin

Source ID Structure
PDB 6LTY
PDB 6LTZ
AlphaFold DB G0THF6

References