143959

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 1064360..1065008 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FOC58_RS05120 Protein ID WP_003899414.1
Coordinates 1064360..1064683 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FOC58_RS05125 Protein ID WP_003899415.1
Coordinates 1064763..1065008 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS05090 1059683..1060681 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FOC58_RS05095 1060695..1061159 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FOC58_RS05100 1061147..1061398 + 252 WP_003908028.1 hypothetical protein -
FOC58_RS05105 1061569..1063008 - 1440 WP_003901443.1 phage major capsid protein -
FOC58_RS05110 1063016..1063549 - 534 WP_003899412.1 HK97 family phage prohead protease -
FOC58_RS05115 1063702..1064193 - 492 WP_079015664.1 phage terminase small subunit P27 family -
FOC58_RS05120 1064360..1064683 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FOC58_RS05125 1064763..1065008 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FOC58_RS05130 1065005..1066432 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FOC58_RS05135 1066434..1066826 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FOC58_RS05140 1066823..1067083 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FOC58_RS05145 1067100..1067462 - 363 WP_003900543.1 hypothetical protein -
FOC58_RS05150 1067465..1068592 - 1128 WP_003899420.1 site-specific integrase -
FOC58_RS05155 1068737..1068964 - 228 WP_003899421.1 hypothetical protein -
FOC58_RS05160 1068961..1069350 - 390 WP_003899422.1 hypothetical protein -
FOC58_RS05165 1069256..1069528 + 273 WP_003900544.1 hypothetical protein -
FOC58_RS05170 1069627..1069860 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1059683..1068592 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T143959 WP_003899414.1 NZ_CP046309:c1064683-1064360 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T143959 NZ_CP061527:c1389252-1388923 [Shigella dysenteriae]
ATGAACTACACTATCGAATACTACAGTGAAGATGTAAGGCTGGAAGTCGATCGGCTTCCATTGAGTATGCGTGCCCGATA
CCAACATCTCGTTGAACGTATGAAGATATATGGCAGCAATCTCGGAGAACCTCACACCAGCGCCTTTGGTGACGGACTTT
TCGAACTCAGAATTAAAGGCAACGATGGGATCGCGCGTGTTTTTTACTGCACTCTGACAGGGAAACGCATCATCATGCTG
CATAGTTTTGTAAAGAAAACGCAGAAAACACCGCCAGCCGAACGCAAGAAAGCTGAAACCAGAATGAAGGAGGTTAAGCA
TGACTGGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT143959 WP_003899415.1 NZ_CP046309:c1065008-1064763 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT143959 NZ_CP061527:c1388933-1388625 [Shigella dysenteriae]
ATGACTGGTAAACGCACTCTCCCCACCATGACACACGACGAAATGGCAGCCAAATGGATGGAAGACCCGGCTTTTAAAGC
AGAATACGACGCTATCGCTGACGAATTCGCACTGCTTGATGAAATGCTGGCAGCACGCAAAGAAGCTGGCTTAACTCAGG
CTGAAGTTGCCGAGCGAATGGGAACAAAAGCGACCGCGATCACCAGAATGGAAAGTAATCTCGCATCAGGTATCAGCGGC
CCATCATTTGCCACCCTAAAAAAATTCGCCCGCGCTACTGGAAAAAAACTCCAGATCCGCTTCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References