Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 867919..868787 | Replicon | chromosome |
| Accession | NZ_CP046308 | ||
| Organism | Mycobacterium tuberculosis strain FDAARGOS_751 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | FOC59_RS03930 | Protein ID | WP_010886136.1 |
| Coordinates | 867919..868296 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | FOC59_RS03935 | Protein ID | WP_003409886.1 |
| Coordinates | 868338..868787 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FOC59_RS03880 | 863708..864160 | - | 453 | WP_003899095.1 | lipoprotein | - |
| FOC59_RS03885 | 864224..864625 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| FOC59_RS03890 | 864618..864800 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| FOC59_RS03895 | 864914..865264 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| FOC59_RS03900 | 865275..866177 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| FOC59_RS03905 | 866198..866389 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| FOC59_RS03910 | 866390..866686 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| FOC59_RS03915 | 866926..867141 | + | 216 | WP_003409878.1 | antitoxin | - |
| FOC59_RS03920 | 867138..867449 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| FOC59_RS20905 | 867423..867944 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| FOC59_RS03930 | 867919..868296 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| FOC59_RS03935 | 868338..868787 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| FOC59_RS03940 | 868784..869329 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| FOC59_RS03945 | 869218..869832 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| FOC59_RS03950 | 869881..870177 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FOC59_RS03955 | 870174..870425 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| FOC59_RS03960 | 870412..870906 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| FOC59_RS03965 | 871066..871473 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| FOC59_RS03970 | 871477..871749 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FOC59_RS03975 | 871782..873002 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T143888 WP_010886136.1 NZ_CP046308:867919-868296 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T143888 NZ_CP061399:353115-353462 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT143888 WP_003409886.1 NZ_CP046308:868338-868787 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT143888 NZ_CP061399:353462-353761 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|