Detailed information of TA system TA143854

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1094006..1094589
• Replicon: chromosome
• Accession: NZ_CP046294
• Organism: Yersinia intermedia strain FDAARGOS_729

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FOC37_RS04935
• Protein ID: WP_005188495.1
• Coordinates: 1094311..1094589 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FOC37_RS04930
• Protein ID: WP_032906974.1
• Coordinates: 1094006..1094311 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC37_RS04915	1090007..1091119	+	1113	WP_032906975.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
FOC37_RS04920	1091123..1091863	+	741	WP_005188504.1	KDGP aldolase family protein	-
FOC37_RS04925	1091988..1093916	+	1929	WP_072103864.1	BglG family transcription antiterminator	-
FOC37_RS04930	1094006..1094311	-	306	WP_032906974.1	HigA family addiction module antidote protein	Antitoxin
FOC37_RS04935	1094311..1094589	-	279	WP_005188495.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOC37_RS04940	1094670..1097402	-	2733	WP_005188491.1	magnesium-translocating P-type ATPase	-
FOC37_RS04945	1097927..1098874	+	948	WP_005188487.1	trehalose operon repressor TreR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-84)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10623.04 Da
• Isoelectric Point: 8.0850

>T143854 WP_005188495.1 NZ_CP046294:c1094589-1094311 [Yersinia intermedia]
MIKSWKHKGLQRFFETGSAAGINPQHVKRLRGRLRFIDLAETIEDVNVAGCKLHSLQGDREGLWSVTVSGNWRITFEFKD
GDAFILNYEDYH

Nucleotide

• Length: 279 bp

>T143854 NZ_CP061385:873275-873685 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11010.78 Da
• Isoelectric Point: 6.0643

>AT143854 WP_032906974.1 NZ_CP046294:c1094311-1094006 [Yersinia intermedia]
MKMHNPPHPGEMIEGILEDLDLGIRELARALNVAPSTVQRLVSCHSAVSPEMAVKLAAVLGSTPAMWLRLQAAYDLGKAE
ENIDISNLTKLYKPDPVSLHN

Nucleotide

• Length: 306 bp

>AT143854 NZ_CP061385:873028-873294 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA