Detailed information of TA system TA143836

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 343165..343748
• Replicon: chromosome
• Accession: NZ_CP046293
• Organism: Yersinia intermedia strain FDAARGOS_730

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FOC38_RS01630
• Protein ID: WP_005188495.1
• Coordinates: 343470..343748 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FOC38_RS01625
• Protein ID: WP_032906974.1
• Coordinates: 343165..343470 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC38_RS01610	339166..340278	+	1113	WP_032906975.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
FOC38_RS01615	340282..341022	+	741	WP_005188504.1	KDGP aldolase family protein	-
FOC38_RS01620	341147..343075	+	1929	WP_072103864.1	BglG family transcription antiterminator	-
FOC38_RS01625	343165..343470	-	306	WP_032906974.1	HigA family addiction module antidote protein	Antitoxin
FOC38_RS01630	343470..343748	-	279	WP_005188495.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOC38_RS01635	343829..346561	-	2733	WP_005188491.1	magnesium-translocating P-type ATPase	-
FOC38_RS01640	347086..348033	+	948	WP_005188487.1	trehalose operon repressor TreR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-84)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10623.04 Da
• Isoelectric Point: 8.0850

>T143836 WP_005188495.1 NZ_CP046293:c343748-343470 [Yersinia intermedia]
MIKSWKHKGLQRFFETGSAAGINPQHVKRLRGRLRFIDLAETIEDVNVAGCKLHSLQGDREGLWSVTVSGNWRITFEFKD
GDAFILNYEDYH

Nucleotide

• Length: 279 bp

>T143836 NZ_CP061379:7090050-7090238 [Bradyrhizobium genosp. B]
ATGAATAGCCGAGACATTATCTCGGCCCTTCAAAGGGATGGCTGGGTCCAAGTGGCTCAAAAAGGCAGCCACGTCCAATT
CAAGCACCTGACCAAAACGGGCCGCGTCACGGTCCCTCATCCAAAGCGGGACATCCCGCTGGGAACGCTGAAAAGCATTG
AACGGCAATCCGGCCTGAAGCTGAGGTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11010.78 Da
• Isoelectric Point: 6.0643

>AT143836 WP_032906974.1 NZ_CP046293:c343470-343165 [Yersinia intermedia]
MKMHNPPHPGEMIEGILEDLDLGIRELARALNVAPSTVQRLVSCHSAVSPEMAVKLAAVLGSTPAMWLRLQAAYDLGKAE
ENIDISNLTKLYKPDPVSLHN

Nucleotide

• Length: 306 bp

>AT143836 NZ_CP061379:7090244-7090642 [Bradyrhizobium genosp. B]
ATGCGTCATTACATCGGTCTGATCCGCAAGGATGCCGACAGCGATTTTGGCGTGTCGTTTCCCGATTTGCCGGGCGTCGT
GACCGCAGGGACCACGCTCGACGAAGCGCGCGACATGGCCGAGGAAGCGCTGGCGTTTCATCTCGAAGGCATGGAGGAAG
ACGGAGAAGCGATTCCAGAACCTTCGTCGCTCGACGAAATCATGTCGAACCCAGAGAACCGCTCCGGCGTGGCCATTCTG
GTGTCGGTGAAGGACGACCAGCCAAAAATCGTGCGCGTCAATGTCACCTTGCCGGGTGATGTCCTGGAGCAGATCGATAA
ATACGCCGAAGCTCACGGCTACACGCGTTCGGGTCTGCTTGCACAGGCCGCCAAGAGGATGATCACGGAAGCGGCGTAA