Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1279108..1279835 Replicon chromosome
Accession NZ_CP046286
Organism Shigella sonnei strain FDAARGOS_715

Toxin (Protein)


Gene name higB Uniprot ID Q3YYE6
Locus tag FOC23_RS07685 Protein ID WP_000547563.1
Coordinates 1279524..1279835 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FOC23_RS07680 Protein ID WP_000126296.1
Coordinates 1279108..1279527 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC23_RS07660 (1274159) 1274159..1274686 - 528 WP_001078777.1 electron transport protein HydN -
FOC23_RS07665 (1274834) 1274834..1275844 - 1011 WP_001402444.1 DNA-binding transcriptional regulator AscG -
FOC23_RS07670 (1276104) 1276104..1277561 + 1458 WP_001107890.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
FOC23_RS07675 (1277570) 1277570..1278994 + 1425 WP_000110319.1 6-phospho-beta-glucosidase AscB -
FOC23_RS07680 (1279108) 1279108..1279527 - 420 WP_000126296.1 helix-turn-helix domain-containing protein Antitoxin
FOC23_RS07685 (1279524) 1279524..1279835 - 312 WP_000547563.1 type II toxin-antitoxin system HigB family toxin Toxin
FOC23_RS07690 (1279997) 1279997..1280770 - 774 WP_001026444.1 hypothetical protein -
FOC23_RS07695 (1280795) 1280795..1281265 - 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
FOC23_RS07700 (1281258) 1281258..1281668 - 411 WP_001291918.1 formate hydrogenlyase assembly protein HycH -
FOC23_RS07705 (1281665) 1281665..1282432 - 768 WP_000067403.1 formate hydrogenlyase subunit HycG -
FOC23_RS07710 (1282432) 1282432..1282974 - 543 WP_000493789.1 formate hydrogenlyase subunit HycF -
FOC23_RS07715 (1282984) 1282984..1284681 - 1698 WP_001288143.1 formate hydrogenlyase subunit HycE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12398.11 Da        Isoelectric Point: 9.7105

>T143816 WP_000547563.1 NZ_CP046286:c1279835-1279524 [Shigella sonnei]
MHIISKAPFEESARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

>T143816 NZ_CP061375:c2748049-2747915 [Xanthomonas oryzae pv. oryzae]
ATGAAGCGTGCAATTGTGCTGCTCGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.38 Da        Isoelectric Point: 4.3653

>AT143816 WP_000126296.1 NZ_CP046286:c1279527-1279108 [Shigella sonnei]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNQEFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp

>AT143816 NZ_CP061375:c2748265-2748113 [Xanthomonas oryzae pv. oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QA22

Antitoxin

Source ID Structure

References