Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 8165363..8165963 Replicon chromosome
Accession NZ_CP046173
Organism Nocardia terpenica strain AUSMDU00012715

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag F6W96_RS36745 Protein ID WP_167490420.1
Coordinates 8165685..8165963 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag F6W96_RS36740 Protein ID WP_167490419.1
Coordinates 8165363..8165671 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W96_RS36710 8160813..8161718 + 906 WP_167490415.1 LysR family transcriptional regulator -
F6W96_RS36715 8161861..8162421 + 561 WP_167490416.1 hypothetical protein -
F6W96_RS36720 8162488..8163270 - 783 WP_167490417.1 hypothetical protein -
F6W96_RS36725 8163382..8163855 - 474 WP_175041437.1 NUDIX domain-containing protein -
F6W96_RS36730 8163839..8164522 - 684 WP_203217845.1 hypothetical protein -
F6W96_RS36735 8164729..8164893 + 165 WP_167490418.1 hypothetical protein -
F6W96_RS36740 8165363..8165671 - 309 WP_167490419.1 HigA family addiction module antidote protein Antitoxin
F6W96_RS36745 8165685..8165963 - 279 WP_167490420.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F6W96_RS36750 8166120..8167103 - 984 WP_167492049.1 c-type cytochrome biogenesis protein CcsB -
F6W96_RS36755 8167106..8168749 - 1644 WP_167490421.1 cytochrome c biogenesis protein ResB -
F6W96_RS36760 8168749..8169582 - 834 WP_167490422.1 cytochrome c biogenesis CcdA family protein -
F6W96_RS36765 8169579..8170175 - 597 WP_167490423.1 TlpA family protein disulfide reductase -
F6W96_RS36770 8170172..8170777 - 606 WP_167492050.1 histidine phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10665.24 Da        Isoelectric Point: 9.7892

>T143714 WP_167490420.1 NZ_CP046173:c8165963-8165685 [Nocardia terpenica]
VIQSFKDKEAQKLWTERSAPKLGNVQKVALRKLTMLDAAAQLDDLRVPPANRLEKLKGDREGQHSIRINDQWRICFVWET
AGPRDVEIINYH

Download         Length: 279 bp

>T143714 NZ_CP061337:c1957163-1957056 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11519.36 Da        Isoelectric Point: 9.9105

>AT143714 WP_167490419.1 NZ_CP046173:c8165671-8165363 [Nocardia terpenica]
MANATPLPPTSPGEILAEEFMEPLRISQNALARALGVPARRINQIVHGKRAITTRTALLLARYFGTTPEFWINLQTHYDL
VREREELSDKLGRIVPRQPLTC

Download         Length: 309 bp

>AT143714 NZ_CP061337:1957211-1957277 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References