Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 7620796..7621487 Replicon chromosome
Accession NZ_CP046172
Organism Nocardia arthritidis strain AUSMDU00012717

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag F5544_RS34285 Protein ID WP_167477010.1
Coordinates 7620796..7621170 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag F5544_RS34290 Protein ID WP_167477011.1
Coordinates 7621167..7621487 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F5544_RS34270 7615818..7617500 + 1683 WP_167477007.1 potassium-transporting ATPase subunit KdpA -
F5544_RS34275 7617497..7619659 + 2163 WP_167477008.1 potassium-transporting ATPase subunit KdpB -
F5544_RS34280 7619664..7620629 + 966 WP_167477009.1 potassium-transporting ATPase subunit C -
F5544_RS34285 7620796..7621170 + 375 WP_167477010.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F5544_RS34290 7621167..7621487 + 321 WP_167477011.1 helix-turn-helix transcriptional regulator Antitoxin
F5544_RS34295 7621532..7621825 + 294 WP_167477012.1 hypothetical protein -
F5544_RS34300 7621816..7622253 - 438 WP_167479665.1 carboxymuconolactone decarboxylase family protein -
F5544_RS34305 7622338..7623873 - 1536 WP_167477013.1 substrate-binding domain-containing protein -
F5544_RS34310 7624067..7625128 - 1062 WP_167477014.1 PHP domain-containing protein -
F5544_RS34315 7625134..7625715 - 582 WP_167477015.1 dihydrofolate reductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-89)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14399.42 Da        Isoelectric Point: 4.5825

>T143711 WP_167477010.1 NZ_CP046172:7620796-7621170 [Nocardia arthritidis]
MDAWEILLTDEVERFLDELYETDRTTHKLVNEAILVLERVGPCQGRPLVDSIVGSNIANLKELRPGSSGRTEIRILFAFD
PWRSAILLVAGDKAGRWQQWYREAIIRAERLYQAYLIEREEEPV

Download         Length: 375 bp

>T143711 NZ_CP061337:c1072732-1072514 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12031.63 Da        Isoelectric Point: 7.0191

>AT143711 WP_167477011.1 NZ_CP046172:7621167-7621487 [Nocardia arthritidis]
MTTFRRWRDSGHLERAIETAGGPEKFEEGVQQLQDWAQGWRLAEMRKRRGLTQREVADQMSISIARVSQIEKGEVSTRDV
LDRYVAALGGKLKLVADFGDEQLLVG

Download         Length: 321 bp

>AT143711 NZ_CP061337:c1073132-1072758 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References