Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 6082134..6082651 Replicon chromosome
Accession NZ_CP046172
Organism Nocardia arthritidis strain AUSMDU00012717

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag F5544_RS27310 Protein ID WP_167475833.1
Coordinates 6082134..6082388 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag F5544_RS27315 Protein ID WP_167475834.1
Coordinates 6082385..6082651 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F5544_RS27295 6077941..6080067 + 2127 WP_167475831.1 MMPL family transporter -
F5544_RS27300 6080369..6081133 - 765 WP_167475832.1 glucose 1-dehydrogenase -
F5544_RS27305 6081203..6082055 - 853 Protein_5391 helix-turn-helix domain-containing protein -
F5544_RS27310 6082134..6082388 - 255 WP_167475833.1 Txe/YoeB family addiction module toxin Toxin
F5544_RS27315 6082385..6082651 - 267 WP_167475834.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F5544_RS27320 6082737..6083057 + 321 WP_167475835.1 helix-turn-helix transcriptional regulator -
F5544_RS27325 6083184..6084920 - 1737 WP_167475836.1 cutinase family protein -
F5544_RS27330 6085162..6086079 - 918 WP_167475837.1 TIGR03621 family F420-dependent LLM class oxidoreductase -
F5544_RS27335 6086168..6086719 - 552 WP_167475838.1 DUF3558 domain-containing protein -
F5544_RS27340 6086716..6087108 - 393 WP_167475839.1 hypothetical protein -
F5544_RS27345 6087179..6087442 - 264 WP_167475840.1 metal-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9948.41 Da        Isoelectric Point: 9.4385

>T143709 WP_167475833.1 NZ_CP046172:c6082388-6082134 [Nocardia arthritidis]
MKITFAKVAWEDFEHWVKTDRKIALRIMRLIGDIERNPFEGLGKPEPLKGDKSGYWSRRIDDEHRLVYSVAGENITVVQA
RYHY

Download         Length: 255 bp

>T143709 NZ_CP061337:386075-386365 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9523.64 Da        Isoelectric Point: 4.1677

>AT143709 WP_167475834.1 NZ_CP046172:c6082651-6082385 [Nocardia arthritidis]
MTTMSASEARANLYPLIEQVNDDAVAIHITSRKGNAVLISEDEYNSLRETLYLLRSPANATRLAQGIAQAEAGDTVEVDM
DTLAKGLE

Download         Length: 267 bp

>AT143709 NZ_CP061337:385843-386085 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCTACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References