Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 576164..576705 Replicon chromosome
Accession NZ_CP046172
Organism Nocardia arthritidis strain AUSMDU00012717

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag F5544_RS02695 Protein ID WP_203217639.1
Coordinates 576164..576421 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag F5544_RS02700 Protein ID WP_167471693.1
Coordinates 576430..576705 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F5544_RS02670 571813..572691 - 879 WP_167471687.1 alpha/beta fold hydrolase -
F5544_RS02675 572804..573967 - 1164 WP_167471688.1 flavin-dependent monooxygenase -
F5544_RS02680 574165..575361 + 1197 WP_167471689.1 3-ketosteroid-9-alpha-hydroxylase subunit A -
F5544_RS02685 575361..575678 + 318 WP_167471690.1 hypothetical protein -
F5544_RS02690 575694..576104 - 411 WP_167471691.1 cupin domain-containing protein -
F5544_RS02695 576164..576421 - 258 WP_203217639.1 Txe/YoeB family addiction module toxin Toxin
F5544_RS02700 576430..576705 - 276 WP_167471693.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
F5544_RS02705 577265..578092 + 828 WP_167478944.1 aminoglycoside phosphotransferase family protein -
F5544_RS02710 578251..579090 + 840 WP_167471694.1 MBL fold metallo-hydrolase -
F5544_RS02715 579087..579836 - 750 WP_167471695.1 DUF427 domain-containing protein -
F5544_RS02720 579869..580315 - 447 WP_167471696.1 MarR family transcriptional regulator -
F5544_RS02725 580362..581399 - 1038 WP_167471697.1 acyl-CoA/acyl-ACP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10129.32 Da        Isoelectric Point: 6.8515

>T143707 WP_203217639.1 NZ_CP046172:c576421-576164 [Nocardia arthritidis]
IAFDPSAWEDYRHWQVVDRAILKKVNRLIEDICRNGNAEGIGKPEALRNNLSGWWSRRITEEHRLVYRCSDDTVHIVSCR
YHYDD

Download         Length: 258 bp

>T143707 NZ_CP061337:275178-275351 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10091.25 Da        Isoelectric Point: 4.5925

>AT143707 WP_167471693.1 NZ_CP046172:c576705-576430 [Nocardia arthritidis]
MRAMHATEARANFAAVLDAATEDNEEVVITRSGGKEPAVVISLREWSAMKETNYLLSSRKNARRLLEAIERAESGAVEYH
DLIDVESKDDA

Download         Length: 276 bp

>AT143707 NZ_CP061337:274854-275150 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References