Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1599662..1600269 Replicon chromosome
Accession NZ_CP046155
Organism Leptolyngbya sp. BL0902

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag GFS31_RS07260 Protein ID WP_198807533.1
Coordinates 1599662..1599955 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GFS31_RS07265 Protein ID WP_198807534.1
Coordinates 1599964..1600269 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFS31_RS07240 1596153..1597148 - 996 WP_198807529.1 adenosine deaminase -
GFS31_RS07245 1597497..1597727 + 231 WP_198807530.1 hypothetical protein -
GFS31_RS07250 1597769..1598896 - 1128 WP_198807531.1 YdcF family protein -
GFS31_RS07255 1598969..1599562 - 594 WP_198807532.1 sulfite oxidase-like oxidoreductase -
GFS31_RS07260 1599662..1599955 + 294 WP_198807533.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GFS31_RS07265 1599964..1600269 + 306 WP_198807534.1 HigA family addiction module antidote protein Antitoxin
GFS31_RS07270 1600327..1601208 + 882 WP_198807535.1 CHAT domain-containing protein -
GFS31_RS07275 1601445..1601603 + 159 WP_198807536.1 hypothetical protein -
GFS31_RS07280 1601600..1603513 + 1914 WP_198807537.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-97)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-97)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10970.33 Da        Isoelectric Point: 7.1328

>T143690 WP_198807533.1 NZ_CP046155:1599662-1599955 [Leptolyngbya sp. BL0902]
MIHSFRNQGTEDIFNGKASKTARATCPQTLWKRAVRKLDQIDSATSVDDLKVPPGNGLELLKGDRTGQYSIRINDQYRIC
FGWVEQGATEVEIVDYH

Download         Length: 294 bp

>T143690 NZ_CP061329:1807824-1808078 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11365.12 Da        Isoelectric Point: 4.7571

>AT143690 WP_198807534.1 NZ_CP046155:1599964-1600269 [Leptolyngbya sp. BL0902]
MRIPTHRSPTHPGEMLLEEFLVPMGLSAEDLAISINVPMAKIEAVISEQQGVTPELALRLAKFFAMSADFWLTLQLRWDL
YRAQQSEAEALAQIHPYQTAS

Download         Length: 306 bp

>AT143690 NZ_CP061329:1807576-1807827 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References