Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1036766..1037409 Replicon chromosome
Accession NZ_CP046114
Organism Glaesserella parasuis strain SCW0912

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GJV39_RS05405 Protein ID WP_021109713.1
Coordinates 1036766..1037110 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GJV39_RS05410 Protein ID WP_021109712.1
Coordinates 1037113..1037409 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJV39_RS05390 1032479..1033107 - 629 Protein_1030 transposase -
GJV39_RS05395 1033370..1034461 - 1092 WP_021109715.1 murein transglycosylase A -
GJV39_RS05400 1034572..1036551 - 1980 WP_021109714.1 exoribonuclease II -
GJV39_RS05405 1036766..1037110 + 345 WP_021109713.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJV39_RS05410 1037113..1037409 + 297 WP_021109712.1 helix-turn-helix domain-containing protein Antitoxin
GJV39_RS05415 1037467..1038129 - 663 WP_021109711.1 Fic family protein -
GJV39_RS05420 1038209..1038997 - 789 WP_005714049.1 SDR family oxidoreductase -
GJV39_RS05425 1039240..1039866 + 627 WP_010786866.1 23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE -
GJV39_RS05430 1039940..1041868 + 1929 WP_021109710.1 ATP-dependent zinc metalloprotease FtsH -
GJV39_RS05435 1041837..1042079 + 243 WP_021109709.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(47-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-76)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13262.28 Da        Isoelectric Point: 7.9640

>T143632 WP_021109713.1 NZ_CP046114:1036766-1037110 [Glaesserella parasuis]
METEEYLTFIKTKVFEEDRKALMSDDEYQKFQAYLLESHELGDFIQNTGGCQKIRWKLESNNKGKSGGVRVIYYVVTKQG
KLLLMMMYAKSKQDNMSDKQKAMLKAVVSQLSEE

Download         Length: 345 bp

>T143632 NZ_CP061295:2008571-2008894 [Polynucleobacter sp. MWH-S4W17]
ATGAGCTATTCCATCCTTTATTACAGCGAGCAGGTTCAAGAAGACATTATGAATCTTCCCGACACGCTTCAAGCTCGCTA
TATTGGATTGACCACTCGAATGATTGAGCATGGGCCGAATTTAGGCTTGCCTCATACGGACTCATTTGGCGGCGGCTTAT
TTGAATTAAGACTTAAAGGGGCTGAAGGTATCGCCCGAGTTTTCTTTTGTACGATGGTGGAGAAAGAAATAGTGATGCTC
CATAGCTTTATTAAGAAGACTCAAAAGACGCCTGAGAAAGAATTAAAGATTGCGAAAGCACGTATGAAGGAGTGGAAAAA
ATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11209.16 Da        Isoelectric Point: 10.0887

>AT143632 WP_021109712.1 NZ_CP046114:1037113-1037409 [Glaesserella parasuis]
MEKELFERLMESAREMVAIEKGEIEVPPHRIHIHKIPNVKAIRTLHQMKQAEFASLLGVSQNLVQSWEIGRRTPNGAARK
LLAIIEQQPNLVPVLQNL

Download         Length: 297 bp

>AT143632 NZ_CP061295:2008915-2009202 [Polynucleobacter sp. MWH-S4W17]
ATGCTTACCCATAAACAAATGATAAGCAAAATGCTTAAAAAGCCAGCTGTAAAAGCCGCAGTCAAAGAACTTGATCGCAC
TGAATTTGCTATTCTTGATGAGATTCTTACGGCAAGGAAAGAGGCTGGATTAACGCAAGCTCAAGTGGCAAAAAAGATGG
GAACACAAACCCCAGCTATTGCTAGATTAGAAAGCTCTCTGGCTACCGGCAAACATTCCCCAAGCCTAACTACCCTAAGA
AAGTATGCGGCGGCCTTGGGCAAGAGAGTTGAGCTTCATTTAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References