Detailed information of TA system TA143621

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2580518..2580917
• Replicon: chromosome
• Accession: NZ_CP046113
• Organism: Enterococcus faecalis strain 092160007-3

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: GKQ54_RS12095
• Protein ID: WP_002368507.1
• Coordinates: 2580720..2580917 (+)
• Length: 66 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2580518..2580662 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GKQ54_RS12085	2576017..2576214	+	198	WP_002372618.1	putative holin-like toxin	-
GKQ54_RS12090	2576404..2580177	-	3774	WP_025193481.1	WxL domain-containing protein	-
-	2580518..2580662	-	145	-	-	Antitoxin
GKQ54_RS12095	2580720..2580917	+	198	WP_002368507.1	putative holin-like toxin	Toxin
GKQ54_RS12100	2581304..2584213	-	2910	WP_029692876.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (32-65)

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7557.14 Da
• Isoelectric Point: 10.6710

>T143621 WP_002368507.1 NZ_CP046113:2580720-2580917 [Enterococcus faecalis]
MCREVMAVAIQSEREVMRMHVFPKFRERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 198 bp

>T143621 NZ_CP061293:1026212-1026502 [Polynucleobacter sp. MWH-Svant-W18]
ATGCTCGAAATCAGGAAAACCGAAGAATTTACAGTCTGGCTAGATTCCCTGAATGATTTGATGGGAAGAGCAAAAATTCA
AGCCCGAATTAAACGTTTGTCCGAAGGAAATTCAGGAATTACAAAATCCGTTGGCAGTAAGGTCTTTGAGATGAAGATTG
ATTTTGGACCCGGCTACAGAATTTATTACACAAAACATGAGAATGTAATGTATCTATTACTTATCGGGGGCAATAAAAGA
ACTCAGGTTAAAGATATTCAGATTGCAAAATATTTAGCCAAAAACATATAG

Antitoxin

Nucleotide

• Length: 145 bp

>AT143621 NZ_CP046113:c2580662-2580518 [Enterococcus faecalis]
TTGTGCTATAATGATAATGAAAAGAGAGATATGCGCTAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTT
TTAGTTACAAAAAATAACCGTACTCAGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGC

Structures

Antitoxin