Detailed information of TA system TA143609

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2435299..2435546
• Replicon: chromosome
• Accession: NZ_CP046113
• Organism: Enterococcus faecalis strain 092160007-3

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: GKQ54_RS11450
• Protein ID: WP_002386265.1
• Coordinates: 2435418..2435546 (-)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2435299..2435473 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GKQ54_RS11425	2430946..2431899	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
GKQ54_RS11430	2431938..2432693	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
GKQ54_RS11435	2432690..2433655	-	966	WP_002387376.1	iron chelate uptake ABC transporter family permease subunit	-
GKQ54_RS11440	2433652..2434599	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
GKQ54_RS11445	2434784..2435236	+	453	WP_002378959.1	YueI family protein	-
-	2435299..2435473	+	175	-	-	Antitoxin
GKQ54_RS11450	2435418..2435546	-	129	WP_002386265.1	hypothetical protein	Toxin
GKQ54_RS11455	2435852..2435981	-	130	Protein_2227	putative holin-like toxin	-
GKQ54_RS11460	2436144..2438414	-	2271	WP_016633839.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
GKQ54_RS11465	2438585..2439085	+	501	WP_016633840.1	cysteine hydrolase	-
GKQ54_RS11470	2439646..2440542	+	897	WP_002354953.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4742.66 Da
• Isoelectric Point: 7.0058

>T143609 WP_002386265.1 NZ_CP046113:c2435546-2435418 [Enterococcus faecalis]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 129 bp

>T143609 NZ_CP061287:c1182037-1181789 [Polynucleobacter sp. MWH-Aus1W21]
TTGCACCTCCAAATTCGCCAAATCGGTAACTCTCGTGGAGTGGTTATTCCAAAGGCTATCCTTGAGCAAGTTGGCTTTGA
GGATGAAGCGGATTTGATTATTGAGGGCAACAGACTGGTGTTAAGTAAGCCCAAAAAAAATCCCCGTGAAGGCTGGGCTG
AGGCTTCAAAAGCAATCGCTGAGGCTAAAGAAGATCACTTAGTATTGGGTGAATTCATGAACGAGGGTGATGAGGATTGG
ATTTGGTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT143609 NZ_CP046113:2435299-2435473 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAA
TCAGTAGTGCAACAA

Structures

Antitoxin