Detailed information of TA system TA143603

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2553505..2553841
• Replicon: chromosome
• Accession: NZ_CP046112
• Organism: Enterococcus faecalis strain 111540027-2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: GKQ55_RS12270
• Protein ID: WP_002381035.1
• Coordinates: 2553505..2553648 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2553792..2553841 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GKQ55_RS12250	2549604..2550233	-	630	WP_002354763.1	lytic polysaccharide monooxygenase	-
GKQ55_RS12255	2550926..2552542	+	1617	WP_002381036.1	phosphatase PAP2/LCP family protein	-
GKQ55_RS12260	2552872..2553015	+	144	WP_002392818.1	putative holin-like toxin	-
-	2552948..2553132	-	185	NuclAT_8	-	-
-	2552989..2553132	-	144	NuclAT_12	-	-
GKQ55_RS12265	2553134..2553274	+	141	WP_073340360.1	putative holin-like toxin	-
-	2553207..2553405	-	199	NuclAT_6	-	-
GKQ55_RS12270	2553505..2553648	+	144	WP_002381035.1	putative holin-like toxin	Toxin
-	2553580..2553842	-	263	NuclAT_10	-	-
-	2553792..2553841	+	50	NuclAT_13	-	Antitoxin
GKQ55_RS12275	2553843..2558534	-	4692	WP_010784674.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T143603 WP_002381035.1 NZ_CP046112:2553505-2553648 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

>T143603 NZ_CP061285:c1302043-1301747 [Polynucleobacter sp. MWH-UH35A]
ATGTTTAAAGTTTTAGAAACAGATAACTTCCGTGAGTGGCTAGGTGGCATTAAAGATCTGTCAACTCGCATTCGATTAGC
TAGGCGCTTGGATAGGGCTAGATTGGGTAATTTGGGAGATGTTAAGGCTTTGGCTGATGGCGTTTACGAAATGCGCGAAA
AGTTTGGGCCTGGTTGGCGTATGTATTACGTATTGAGAGGTAAAACAATTATTGTGGTGTTGGGTGGTGGAGATAAGTCC
AGTCAAGTAAGTGATATTAAAGCGGCAAAAAAATTAGCCAAGCTATTGGAGGATTAA

Antitoxin

Nucleotide

• Length: 50 bp

>AT143603 NZ_CP046112:2553792-2553841 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin