Detailed information of TA system TA143591

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2552948..2553274
• Replicon: chromosome
• Accession: NZ_CP046112
• Organism: Enterococcus faecalis strain 111540027-2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A3N3Z2N6
• Locus tag: GKQ55_RS12265
• Protein ID: WP_073340360.1
• Coordinates: 2553134..2553274 (+)
• Length: 47 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2552948..2553132 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GKQ55_RS12240	2547994..2548209	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
GKQ55_RS12245	2548348..2549340	+	993	WP_142426550.1	biotin--[acetyl-CoA-carboxylase] ligase	-
GKQ55_RS12250	2549604..2550233	-	630	WP_002354763.1	lytic polysaccharide monooxygenase	-
GKQ55_RS12255	2550926..2552542	+	1617	WP_002381036.1	phosphatase PAP2/LCP family protein	-
GKQ55_RS12260	2552872..2553015	+	144	WP_002392818.1	putative holin-like toxin	-
-	2552948..2553132	-	185	NuclAT_8	-	Antitoxin
-	2552989..2553132	-	144	NuclAT_12	-	-
GKQ55_RS12265	2553134..2553274	+	141	WP_073340360.1	putative holin-like toxin	Toxin
-	2553207..2553405	-	199	NuclAT_6	-	-
GKQ55_RS12270	2553505..2553648	+	144	WP_002381035.1	putative holin-like toxin	-
-	2553580..2553842	-	263	NuclAT_10	-	-
-	2553792..2553841	+	50	NuclAT_13	-	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-46)

Sequences

Toxin

Protein

• Length: 47 a.a.
• Molecular weight: 5218.33 Da
• Isoelectric Point: 10.3265

>T143591 WP_073340360.1 NZ_CP046112:2553134-2553274 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 141 bp

>T143591 NZ_CP061208:c1595959-1595780 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin

Nucleotide

• Length: 185 bp

>AT143591 NZ_CP046112:c2553132-2552948 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A3N3Z2N6

Antitoxin