Detailed information of TA system TA143578

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2395226..2395478
• Replicon: chromosome
• Accession: NZ_CP046112
• Organism: Enterococcus faecalis strain 111540027-2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: GKQ55_RS11540
• Protein ID: WP_002393909.1
• Coordinates: 2395350..2395478 (-)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2395226..2395405 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GKQ55_RS11510	2390442..2391395	-	954	WP_002404024.1	siderophore ABC transporter substrate-binding protein	-
GKQ55_RS11515	2391434..2392189	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
GKQ55_RS11520	2392186..2393151	-	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
GKQ55_RS11525	2393148..2394095	-	948	WP_174776051.1	iron chelate uptake ABC transporter family permease subunit	-
GKQ55_RS11530	2394280..2394732	+	453	WP_002354958.1	YueI family protein	-
-	2394758..2394968	+	211	NuclAT_4	-	-
-	2394795..2394972	+	178	NuclAT_3	-	-
GKQ55_RS11535	2394917..2395044	-	128	Protein_2266	putative holin-like toxin	-
-	2395192..2395401	+	210	NuclAT_5	-	-
-	2395226..2395405	+	180	NuclAT_2	-	Antitoxin
GKQ55_RS11540	2395350..2395478	-	129	WP_002393909.1	hypothetical protein	Toxin
GKQ55_RS11545	2395641..2397911	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
GKQ55_RS11550	2398082..2398582	+	501	WP_002354954.1	cysteine hydrolase	-
GKQ55_RS11555	2399129..2400025	+	897	WP_002365354.1	YitT family protein	-
GKQ55_RS11560	2400076..2400474	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4743.64 Da
• Isoelectric Point: 5.6470

>T143578 WP_002393909.1 NZ_CP046112:c2395478-2395350 [Enterococcus faecalis]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 129 bp

>T143578 NZ_CP061206:3987880-3988134 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Nucleotide

• Length: 180 bp

>AT143578 NZ_CP046112:2395226-2395405 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Structures

Antitoxin