Detailed information of TA system TA143570

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 541715..542001
• Replicon: chromosome
• Accession: NZ_CP046111
• Organism: Enterococcus faecalis strain 111540047-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: GKQ56_RS02690
• Protein ID: WP_002393909.1
• Coordinates: 541715..541843 (+)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	541792..542001 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GKQ56_RS02670	536719..537117	+	399	WP_002354951.1	glyoxalase	-
GKQ56_RS02675	537168..538064	-	897	WP_002365354.1	YitT family protein	-
GKQ56_RS02680	538611..539111	-	501	WP_002354954.1	cysteine hydrolase	-
GKQ56_RS02685	539282..541552	+	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
GKQ56_RS02690	541715..541843	+	129	WP_002393909.1	hypothetical protein	Toxin
-	541788..541967	-	180	NuclAT_2	-	-
-	541792..542001	-	210	NuclAT_5	-	Antitoxin
GKQ56_RS02695	542149..542276	+	128	Protein_499	putative holin-like toxin	-
-	542221..542398	-	178	NuclAT_3	-	-
-	542225..542435	-	211	NuclAT_4	-	-
GKQ56_RS02700	542461..542913	-	453	WP_002354958.1	YueI family protein	-
GKQ56_RS02705	543098..544045	+	948	WP_174776051.1	iron chelate uptake ABC transporter family permease subunit	-
GKQ56_RS02710	544042..545007	+	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
GKQ56_RS02715	545004..545759	+	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
GKQ56_RS02720	545798..546751	+	954	WP_002404024.1	siderophore ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4743.64 Da
• Isoelectric Point: 5.6470

>T143570 WP_002393909.1 NZ_CP046111:541715-541843 [Enterococcus faecalis]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 129 bp

>T143570 NZ_CP061206:c1900995-1900684 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Nucleotide

• Length: 210 bp

>AT143570 NZ_CP046111:c542001-541792 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin