Detailed information of TA system TA143561

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-RNAII/-
• Location: 469184..469647
• Replicon: chromosome
• Accession: NZ_CP046111
• Organism: Enterococcus faecalis strain 111540047-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: GKQ56_RS02345
• Protein ID: WP_002392696.1
• Coordinates: 469504..469647 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	469184..469328 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GKQ56_RS02325	466237..466791	+	555	WP_002354869.1	septum formation protein Maf	-
GKQ56_RS02330	466924..467361	+	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
GKQ56_RS02335	467536..468507	+	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
GKQ56_RS02340	468560..468754	-	195	Protein_428	CPBP family intramembrane metalloprotease	-
-	469184..469328	-	145	NuclAT_11	-	Antitoxin
GKQ56_RS02345	469504..469647	+	144	WP_002392696.1	putative holin-like toxin	Toxin
-	469580..469767	-	188	NuclAT_7	-	-
GKQ56_RS02350	469888..470482	-	595	Protein_430	hypothetical protein	-
-	470761..470842	-	82	NuclAT_9	-	-
GKQ56_RS02355	470897..471547	-	651	WP_002354875.1	beta-phosphoglucomutase	-
GKQ56_RS02360	471562..474306	-	2745	WP_002404005.1	glycoside hydrolase family 65 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T143561 WP_002392696.1 NZ_CP046111:469504-469647 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T143561 NZ_CP061205:3884053-3884916 [Kordiimonas pumila]
ATGGTTAAAGTCAGCCCAGTGTCCATCAAACAGCGCCTCCATAATCATGCCCGATCCAGTGGACGTGTCTACAATACTGT
CCTCATCGCCTATGGCCTGCAAAGGCTTATATACCGCCTATCTGTATCAAAGCATGCAAATGATTATATCCTTAAGGGCG
GCATGTTAGTAACACAGTGGACACTCGATAGTGTACGGCCAACAAAAGACCTGGACTTTTTGGGCTTCGGAGACAGTGAC
GCAGACCATCTGATAGATGTGTTCTCCGAAGTCATGGAACTAGATGGAGATGACGGCCTTAACTTTGACACGGCAACACT
CGCCGCCACCCCTATAAGGGATACGCAAGATTATGGTGGCATCCGCCTCAAAACAACAGCCTATCTAGACAAAACAAAAA
TACCGATCACCATTGATGTCGGATTTGGGGATGCCATCGTGGACCCTGACTACCGTATTGACTATCCATCCCTATTAGAT
ATGCCGCCTGCAACCTTGCGGGCTTATCCGCCAGAATCCGTCATTGCAGAGAAGTTTCATGCAGTGGTCGCGCTCGGCCT
GATCAACAGCCGGATGAAAGACTATTATGATCTTTGGTCGATACCACAAGCTCTAGCCCTCAATGAGGACATGCTTGATA
AGGCGATTGCAGAGACGTTCAAACGGCGCGGCCATGCTATACCGACAACATGCCCACCCGGGTTCTCGGACATGTTCGCT
GAAGACGCCGAGAAAAAACGCCAATGGGCTGCCTACGCTGAATCGGTAAATCTTGAGAATGTCAGCCTGCAACGAGTCAC
AGAGGAAATTTGGGATTATTTAGCTCCCGCCTGTGCGAGAATCTGCAAACGTGAGGAAACCTAG

Antitoxin

Nucleotide

• Length: 145 bp

>AT143561 NZ_CP046111:c469328-469184 [Enterococcus faecalis]
TTGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCGAT
TTTGTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAACA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin