Detailed information of TA system TA143539

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): fst-RNAII/Fst(toxin)
• Location: 72367..72608
• Replicon: plasmid pAD1
• Accession: NZ_CP046109
• Organism: Enterococcus faecalis strain 133170041-3

Toxin (Protein)

• Gene name: fst
• Uniprot ID: -
• Locus tag: GKQ57_RS14330
• Protein ID: WP_002360667.1
• Coordinates: 72367..72477 (+)
• Length: 37 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	72517..72608 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GKQ57_RS14290	67646..67948	+	303	WP_002367825.1	hypothetical protein	-
GKQ57_RS14295	68288..68908	+	621	WP_021732893.1	recombinase family protein	-
GKQ57_RS14300	68925..69212	+	288	WP_010708491.1	hypothetical protein	-
GKQ57_RS14305	69206..69430	+	225	WP_010708492.1	hypothetical protein	-
GKQ57_RS14310	69491..69700	+	210	WP_002387638.1	hypothetical protein	-
GKQ57_RS14315	69712..70014	+	303	WP_002365939.1	hypothetical protein	-
GKQ57_RS14320	70441..71769	+	1329	WP_021732894.1	Y-family DNA polymerase	-
GKQ57_RS14325	71766..72116	+	351	WP_002399364.1	hypothetical protein	-
GKQ57_RS14330	72367..72477	+	111	WP_002360667.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	72517..72608	-	92	NuclAT_0	-	Antitoxin
-	72517..72608	-	92	NuclAT_0	-	Antitoxin
-	72517..72608	-	92	NuclAT_0	-	Antitoxin
-	72517..72608	-	92	NuclAT_0	-	Antitoxin
GKQ57_RS14335	72717..73013	+	297	WP_002360665.1	replication control protein PrgN	-
GKQ57_RS14340	73267..74049	+	783	WP_002360664.1	ParA family protein	-
GKQ57_RS14345	74042..74398	+	357	WP_002360663.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	prgB/asc10	1..74657	74657

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 37 a.a.
• Molecular weight: 4117.92 Da
• Isoelectric Point: 4.1672

>T143539 WP_002360667.1 NZ_CP046109:72367-72477 [Enterococcus faecalis]
VLFVKDLMSLVIAPIFVGLVLEMISRVLDEEDDNRK

Nucleotide

• Length: 111 bp

>T143539 NZ_CP061185:c4626610-4626503 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 92 bp

>AT143539 NZ_CP046109:c72608-72517 [Enterococcus faecalis]
TAAAAATATGTTATACTAAAGGTGCGAAACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGA
TTGCTTTTTTTT

Structures

Antitoxin