Detailed information of TA system TA143530

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 426883..427169
• Replicon: chromosome
• Accession: NZ_CP046108
• Organism: Enterococcus faecalis strain 133170041-3

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: GKQ57_RS01975
• Protein ID: WP_002393909.1
• Coordinates: 426883..427011 (+)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	426960..427169 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GKQ57_RS01955	422035..422433	+	399	WP_002354951.1	glyoxalase	-
GKQ57_RS01960	422484..423380	-	897	WP_002365354.1	YitT family protein	-
GKQ57_RS01965	423779..424279	-	501	WP_002365352.1	cysteine hydrolase	-
GKQ57_RS01970	424450..426720	+	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
GKQ57_RS01975	426883..427011	+	129	WP_002393909.1	hypothetical protein	Toxin
-	426960..427169	-	210	-	-	Antitoxin
GKQ57_RS01980	427317..427444	+	128	Protein_384	putative holin-like toxin	-
GKQ57_RS01985	427629..428081	-	453	WP_002354958.1	YueI family protein	-
GKQ57_RS01990	428266..429213	+	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
GKQ57_RS01995	429210..430175	+	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
GKQ57_RS02000	430172..430927	+	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
GKQ57_RS02005	430966..431919	+	954	WP_002365350.1	siderophore ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4743.64 Da
• Isoelectric Point: 5.6470

>T143530 WP_002393909.1 NZ_CP046108:426883-427011 [Enterococcus faecalis]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 129 bp

>T143530 NZ_CP061185:c2636867-2636764 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 210 bp

>AT143530 NZ_CP046108:c427169-426960 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin