Detailed information of TA system TA143483

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 3084386..3084905
• Replicon: chromosome
• Accession: NZ_CP046058
• Organism: Microcystis aeruginosa NIES-298

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: I4HB24
• Locus tag: D3800_RS14470
• Protein ID: WP_002756029.1
• Coordinates: 3084386..3084652 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: D3800_RS14475
• Protein ID: WP_103112370.1
• Coordinates: 3084645..3084905 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D3800_RS14435	3081289..3081546	-	258	WP_043997184.1	hypothetical protein	-
D3800_RS14440	3081694..3081900	+	207	WP_002754857.1	XRE family transcriptional regulator	-
D3800_RS14445	3081930..3082259	+	330	WP_002754856.1	hypothetical protein	-
D3800_RS14450	3082266..3082526	+	261	WP_002754855.1	DUF4926 domain-containing protein	-
D3800_RS14455	3082589..3082840	-	252	WP_069475141.1	BrnA antitoxin family protein	-
D3800_RS14460	3082785..3083096	-	312	WP_061430167.1	BrnT family toxin	-
D3800_RS14465	3083437..3083925	+	489	WP_103112437.1	hypothetical protein	-
D3800_RS14470	3084386..3084652	-	267	WP_002756029.1	Txe/YoeB family addiction module toxin	Toxin
D3800_RS14475	3084645..3084905	-	261	WP_103112370.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D3800_RS14485	3085997..3086953	+	957	WP_002756024.1	ribonuclease Z	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10459.08 Da
• Isoelectric Point: 9.9458

>T143483 WP_002756029.1 NZ_CP046058:c3084652-3084386 [Microcystis aeruginosa NIES-298]
MDNWQLVFTKQAKKDAEKLARTGLAKQANELLNILKSNPYQSYPVYEKLSGDLASYYSRRINIQHRLVYQVIPEEKVVKV
IRMWTHYE

Nucleotide

• Length: 267 bp

>T143483 NZ_CP061108:4327512-4327886 [Escherichia coli]
ATGAACACATTACCCGATACACACATACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9474.64 Da
• Isoelectric Point: 3.8305

>AT143483 WP_103112370.1 NZ_CP046058:c3084905-3084645 [Microcystis aeruginosa NIES-298]
MKIVTVTEAKEQIDELVNDTNDNHQPILLSGTKKNAILIAEEDWNSIQETLYLYSIPGMVDSIIEGGNTSIEDCVDEAVI
RAILNG

Nucleotide

• Length: 261 bp

>AT143483 NZ_CP061108:4327054-4327422 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A822LG33