Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1938536..1939141 Replicon chromosome
Accession NZ_CP046058
Organism Microcystis aeruginosa NIES-298

Toxin (Protein)


Gene name higB Uniprot ID I4FMI0
Locus tag D3800_RS09355 Protein ID WP_002740810.1
Coordinates 1938860..1939141 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D3800_RS09350 Protein ID WP_002737909.1
Coordinates 1938536..1938850 (-) Length 105 a.a.

Genomic Context

D3800_RS09360D3800_RS09365D3800_RS09340D3800_RS09345D3800_RS09350D3800_RS09355D3800_RS23960D3800_RS09370D3800_RS09375D3800_RS09380
Location: 1939780..1940040 (261 bp)
Type: Others
Protein ID: WP_002740817.1
Location: 1940027..1940449 (423 bp)
Type: Others
Protein ID: WP_103112650.1
Location: 1936566..1937915 (1350 bp)
Type: Others
Protein ID: WP_103112652.1
Location: 1938095..1938367 (273 bp)
Type: Others
Protein ID: WP_103112651.1
Location: 1938536..1938850 (315 bp)
Type: Antitoxin
Protein ID: WP_002737909.1
Location: 1938860..1939141 (282 bp)
Type: Toxin
Protein ID: WP_002740810.1
Location: 1939441..1939599 (159 bp)
Type: Others
Protein ID: WP_180995421.1
Location: 1940561..1940842 (282 bp)
Type: Others
Protein ID: WP_002736843.1
Location: 1941024..1943546 (2523 bp)
Type: Others
Protein ID: WP_103112649.1
Location: 1943745..1944038 (294 bp)
Type: Others
Protein ID: WP_103112648.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
D3800_RS093401936566..1937915-1350WP_103112652.1AAA family ATPase-
D3800_RS093451938095..1938367-273WP_103112651.1hypothetical protein-
D3800_RS093501938536..1938850-315WP_002737909.1HigA family addiction module antidote proteinAntitoxin
D3800_RS093551938860..1939141-282WP_002740810.1type II toxin-antitoxin system RelE/ParE family toxinToxin
D3800_RS239601939441..1939599-159WP_180995421.1hypothetical protein-
D3800_RS093601939780..1940040+261WP_002740817.1hypothetical protein-
D3800_RS093651940027..1940449+423WP_103112650.1PIN domain-containing protein-
D3800_RS093701940561..1940842-282WP_002736843.1hemolysin XhlA family protein-
D3800_RS093751941024..1943546-2523WP_103112649.1glycogen/starch/alpha-glucan phosphorylase-
D3800_RS093801943745..1944038-294WP_103112648.1RNA-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-92)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11127.76 Da        Isoelectric Point: 9.7184

>T143481 WP_002740810.1 NZ_CP046058:c1939141-1938860 [Microcystis aeruginosa NIES-298]
VIQNFKDKEAQKVFERKHSRKLPLDIQQVALRKLRMLNRAETLQDLRVPPANRLERLVGDREGQYSIRVNDQWRICFVWQ
NGDALDVEIVDYH

Download         Length: 282 bp

>T143481 NZ_CP061108:2730489-2730596 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGTGTAACCGGAAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11846.78 Da        Isoelectric Point: 4.1648

>AT143481 WP_002737909.1 NZ_CP046058:c1938850-1938536 [Microcystis aeruginosa NIES-298]
MNEDKLMPIHPGEVLLEEFIKPMNLSQNQIALALGVPEQCINEIVHGKRCITADIALRLARYFDMSPRFWLGLQMDYDLD
VVEDEIGDQLDKEVAVMTVICAEK

Download         Length: 315 bp

>AT143481 NZ_CP061108:c2730436-2730375 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBI4FMI0

Antitoxin

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Source
ID
Structure
No matching records found

References