Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1938536..1939141 Replicon chromosome
Accession NZ_CP046058
Organism Microcystis aeruginosa NIES-298

Toxin (Protein)


Gene name higB Uniprot ID I4FMI0
Locus tag D3800_RS09355 Protein ID WP_002740810.1
Coordinates 1938860..1939141 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D3800_RS09350 Protein ID WP_002737909.1
Coordinates 1938536..1938850 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D3800_RS09340 1936566..1937915 - 1350 WP_103112652.1 AAA family ATPase -
D3800_RS09345 1938095..1938367 - 273 WP_103112651.1 hypothetical protein -
D3800_RS09350 1938536..1938850 - 315 WP_002737909.1 HigA family addiction module antidote protein Antitoxin
D3800_RS09355 1938860..1939141 - 282 WP_002740810.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D3800_RS23960 1939441..1939599 - 159 WP_180995421.1 hypothetical protein -
D3800_RS09360 1939780..1940040 + 261 WP_002740817.1 hypothetical protein -
D3800_RS09365 1940027..1940449 + 423 WP_103112650.1 PIN domain-containing protein -
D3800_RS09370 1940561..1940842 - 282 WP_002736843.1 hemolysin XhlA family protein -
D3800_RS09375 1941024..1943546 - 2523 WP_103112649.1 glycogen/starch/alpha-glucan phosphorylase -
D3800_RS09380 1943745..1944038 - 294 WP_103112648.1 RNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-92)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11127.76 Da        Isoelectric Point: 9.7184

>T143481 WP_002740810.1 NZ_CP046058:c1939141-1938860 [Microcystis aeruginosa NIES-298]
VIQNFKDKEAQKVFERKHSRKLPLDIQQVALRKLRMLNRAETLQDLRVPPANRLERLVGDREGQYSIRVNDQWRICFVWQ
NGDALDVEIVDYH

Download         Length: 282 bp

>T143481 NZ_CP061108:2730489-2730596 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGTGTAACCGGAAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11846.78 Da        Isoelectric Point: 4.1648

>AT143481 WP_002737909.1 NZ_CP046058:c1938850-1938536 [Microcystis aeruginosa NIES-298]
MNEDKLMPIHPGEVLLEEFIKPMNLSQNQIALALGVPEQCINEIVHGKRCITADIALRLARYFDMSPRFWLGLQMDYDLD
VVEDEIGDQLDKEVAVMTVICAEK

Download         Length: 315 bp

>AT143481 NZ_CP061108:c2730436-2730375 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I4FMI0

Antitoxin

Source ID Structure

References