Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1630573..1631138 Replicon chromosome
Accession NZ_CP046058
Organism Microcystis aeruginosa NIES-298

Toxin (Protein)


Gene name higB Uniprot ID A0A2H6BV23
Locus tag D3800_RS07840 Protein ID WP_024968549.1
Coordinates 1630860..1631138 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D3800_RS07835 Protein ID WP_002767514.1
Coordinates 1630573..1630860 (-) Length 96 a.a.

Genomic Context

D3800_RS07805D3800_RS07810D3800_RS07815D3800_RS07820D3800_RS07825D3800_RS07830D3800_RS07835D3800_RS07840D3800_RS07845D3800_RS07850D3800_RS07855D3800_RS07860D3800_RS07870
Location: 1625655..1626341 (687 bp)
Type: Others
Protein ID: WP_103112766.1
Location: 1626583..1628010 (1428 bp)
Type: Others
Protein ID: WP_004158996.1
Location: 1628110..1628988 (879 bp)
Type: Others
Protein ID: WP_103112767.1
Location: 1628989..1629534 (546 bp)
Type: Others
Protein ID: WP_016514523.1
Location: 1629564..1630010 (447 bp)
Type: Others
Protein ID: WP_103112768.1
Location: 1630017..1630286 (270 bp)
Type: Others
Protein ID: WP_103112841.1
Location: 1630573..1630860 (288 bp)
Type: Antitoxin
Protein ID: WP_002767514.1
Location: 1630860..1631138 (279 bp)
Type: Toxin
Protein ID: WP_024968549.1
Location: 1631442..1631834 (393 bp)
Type: Others
Protein ID: WP_103112769.1
Location: 1631831..1632208 (378 bp)
Type: Others
Protein ID: WP_002778608.1
Location: 1632422..1632799 (378 bp)
Type: Others
Protein ID: WP_002736741.1
Location: 1632796..1633068 (273 bp)
Type: Others
Protein ID: WP_002736754.1
Location: 1633508..1634320 (813 bp)
Type: Others
Protein ID: WP_103112770.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
D3800_RS078051625655..1626341+687WP_103112766.1hypothetical protein-
D3800_RS078101626583..1628010+1428WP_004158996.1UDP-N-acetylmuramate--L-alanine ligase-
D3800_RS078151628110..1628988+879WP_103112767.1UDP-N-acetylmuramate dehydrogenase-
D3800_RS078201628989..1629534-546WP_016514523.1hypothetical protein-
D3800_RS078251629564..1630010-447WP_103112768.1hypothetical protein-
D3800_RS078301630017..1630286-270WP_103112841.1hypothetical protein-
D3800_RS078351630573..1630860-288WP_002767514.1HigA family addiction module antidote proteinAntitoxin
D3800_RS078401630860..1631138-279WP_024968549.1type II toxin-antitoxin system RelE/ParE family toxinToxin
D3800_RS078451631442..1631834-393WP_103112769.1ACP S-malonyltransferase-
D3800_RS078501631831..1632208-378WP_002778608.1DUF433 domain-containing protein-
D3800_RS078551632422..1632799-378WP_002736741.1hypothetical protein-
D3800_RS078601632796..1633068-273WP_002736754.1hypothetical protein-
D3800_RS078701633508..1634320-813WP_103112770.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10369.75 Da        Isoelectric Point: 7.3596

>T143476 WP_024968549.1 NZ_CP046058:c1631138-1630860 [Microcystis aeruginosa NIES-298]
MIVSFKHRGLEQFFESGTTRGIQANHAQRIRLILARLSAATSPQDMNLPGLVLHELAGQRKGTWTVRVSGNWRITFTFDG
VDACDVDLEDYH

Download         Length: 279 bp

>T143476 NZ_CP061108:1849980-1850231 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10511.20 Da        Isoelectric Point: 7.1657

>AT143476 WP_002767514.1 NZ_CP046058:c1630860-1630573 [Microcystis aeruginosa NIES-298]
MKMHNPPHPGEVLKELCLEPLNLTVTEAAEALGVSRKTLSAILNGRAGISPEMAIRLGKAFDTSPESWLNQQMQYDLWQA
EQTIGNIKVKRLSVV

Download         Length: 288 bp

>AT143476 NZ_CP061108:1850228-1850482 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2H6BV23

Antitoxin

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Source
ID
Structure
No matching records found

References