Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1273351..1274174 Replicon chromosome
Accession NZ_CP046058
Organism Microcystis aeruginosa NIES-298

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag D3800_RS05945 Protein ID WP_103111352.1
Coordinates 1273351..1273848 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag D3800_RS05950 Protein ID WP_202861573.1
Coordinates 1273851..1274174 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D3800_RS05930 1269398..1270423 + 1026 WP_002732998.1 ABC transporter permease -
D3800_RS05935 1270876..1271733 - 858 WP_162205119.1 IS5 family transposase -
D3800_RS05940 1272294..1273005 + 712 Protein_1177 IS1 family transposase -
D3800_RS05945 1273351..1273848 - 498 WP_103111352.1 type II toxin-antitoxin system YhaV family toxin Toxin
D3800_RS05950 1273851..1274174 - 324 WP_202861573.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
D3800_RS05955 1274444..1275622 + 1179 WP_002732401.1 AI-2E family transporter -
D3800_RS05960 1276515..1276982 - 468 WP_103111349.1 hypothetical protein -
D3800_RS05965 1276960..1277172 - 213 WP_103111367.1 hypothetical protein -
D3800_RS05970 1277195..1277767 - 573 WP_103111348.1 hypothetical protein -
D3800_RS05975 1277922..1278755 - 834 WP_103111347.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1270876..1271769 893


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(14-151)

Antitoxin

PrlF antitoxin

(6-104)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 19741.31 Da        Isoelectric Point: 7.4613

>T143475 WP_103111352.1 NZ_CP046058:c1273848-1273351 [Microcystis aeruginosa NIES-298]
MSIDQPLVINGWSIFAHPLFLEQFEELVTQVEELRHKFPQDYKRKNATKRLAAIAKLAFDTIPQDPTRSDYRQGTTLGDD
YKHWFRAKFFQQYRLFFRYHQESKIILLAWVNDENSKRAYESSTDAYRVFRKMLETSYPPDDWHDLLKEAKSTISRLREA
AETEI

Download         Length: 498 bp

>T143475 NZ_CP061108:1347611-1348009 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12035.48 Da        Isoelectric Point: 4.1961

>AT143475 WP_202861573.1 NZ_CP046058:c1274174-1273851 [Microcystis aeruginosa NIES-298]
MAPWPESTLTDRYQTTIPDSVRKALGLNKRDKICYNIQPDGKVWISRADGTEENDPVLGKFLNFLAQDMEQNPQHIQAIS
SNLVNHVQCLVSGVDLELDAPLLDEDE

Download         Length: 324 bp

>AT143475 NZ_CP061108:1347384-1347611 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References