143452

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1991724..1992310 Replicon chromosome
Accession NZ_CP046045
Organism Acinetobacter towneri strain 19110F47

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GJD93_RS10710 Protein ID WP_104853185.1
Coordinates 1991724..1992032 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag GJD93_RS10715 Protein ID WP_004971994.1
Coordinates 1992029..1992310 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJD93_RS10690 1987477..1987944 + 468 WP_131261606.1 GNAT family N-acetyltransferase -
GJD93_RS10695 1988046..1989662 - 1617 WP_154320938.1 sulfate adenylyltransferase subunit CysN -
GJD93_RS10700 1989807..1990715 - 909 WP_171501131.1 sulfate adenylyltransferase subunit CysD -
GJD93_RS10705 1991068..1991598 + 531 WP_154320940.1 hypothetical protein -
GJD93_RS10710 1991724..1992032 + 309 WP_104853185.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJD93_RS10715 1992029..1992310 + 282 WP_004971994.1 HigA family addiction module antidote protein Antitoxin
GJD93_RS10720 1992384..1993910 - 1527 WP_096900968.1 lysine--tRNA ligase -
GJD93_RS10725 1994227..1994733 + 507 WP_026438299.1 alpha/beta fold hydrolase -
GJD93_RS10730 1994844..1995386 - 543 WP_004972003.1 adenine phosphoribosyltransferase -
GJD93_RS10735 1995871..1996035 + 165 WP_004972007.1 rubredoxin -
GJD93_RS10740 1996108..1997286 + 1179 WP_154320941.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-80)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11468.07 Da        Isoelectric Point: 10.2252

>T143452 WP_104853185.1 NZ_CP046045:1991724-1992032 [Acinetobacter towneri]
MIKSFKHKGLQAFFQTGSTAGIQAAHSTKLRLILAALHAASTVNDLRTPPNWRLHKLSANLQDQWSLTVNGNWRVIFKFE
DGDVYIVDYLDYHIASSAGVQR

Download         Length: 309 bp

>T143452 NZ_CP061101:2719076-2719183 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10451.10 Da        Isoelectric Point: 6.7228

>AT143452 WP_004971994.1 NZ_CP046045:1992029-1992310 [Acinetobacter towneri]
MNMMFNAPHPGEMLREYIGETSVTEVAQALGVTRANLSRILNGHTGISADMAIRLSEALETSPEFWLNLQMQHDLWLASQ
RQRPMIKKLVASV

Download         Length: 282 bp

>AT143452 NZ_CP061101:c2719029-2718963 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References