Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 207651..208227 Replicon chromosome
Accession NZ_CP046045
Organism Acinetobacter towneri strain 19110F47

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GJD93_RS02010 Protein ID WP_154320212.1
Coordinates 207916..208227 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GJD93_RS02005 Protein ID WP_154320211.1
Coordinates 207651..207923 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJD93_RS01955 203320..204156 + 837 WP_000480968.1 aminoglycoside O-phosphotransferase APH(6)-Id -
GJD93_RS01965 204377..204734 + 358 Protein_194 type II toxin-antitoxin system RelE/ParE family toxin -
GJD93_RS01970 204727..205029 + 303 WP_001140620.1 XRE family transcriptional regulator -
GJD93_RS01975 205162..205575 + 414 WP_070155403.1 hypothetical protein -
GJD93_RS01980 205578..205892 + 315 WP_070155405.1 hypothetical protein -
GJD93_RS01985 205958..206251 - 294 WP_154320209.1 type II toxin-antitoxin system RelE/ParE family toxin -
GJD93_RS01990 206241..206486 - 246 WP_000246756.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GJD93_RS01995 206654..207082 + 429 WP_004786455.1 organic hydroperoxide resistance protein -
GJD93_RS02000 207089..207520 + 432 WP_154320210.1 MarR family transcriptional regulator -
GJD93_RS02005 207651..207923 - 273 WP_154320211.1 helix-turn-helix domain-containing protein Antitoxin
GJD93_RS02010 207916..208227 - 312 WP_154320212.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJD93_RS02015 208359..209684 - 1326 WP_154320213.1 ISNCY family transposase -
GJD93_RS02020 209857..210156 - 300 WP_000358348.1 hypothetical protein -
GJD93_RS02025 210244..210537 - 294 WP_004733298.1 type II toxin-antitoxin system RelE/ParE family toxin -
GJD93_RS02030 210527..210772 - 246 WP_070154357.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GJD93_RS02035 210942..211268 - 327 WP_004676063.1 hypothetical protein -
GJD93_RS02040 211265..211687 - 423 WP_004676061.1 hypothetical protein -
GJD93_RS02045 211791..212114 + 324 WP_004676058.1 hypothetical protein -
GJD93_RS02050 212300..212977 + 678 WP_127801904.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn floR / tet(X4) / sul2 / aph(3'')-Ib / aph(6)-Id - 184462..209696 25234


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(38-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11815.47 Da        Isoelectric Point: 7.9849

>T143447 WP_154320212.1 NZ_CP046045:c208227-207916 [Acinetobacter towneri]
IETSIFTKQIKDLVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAYPKS
VKDNLTDKETAILRQLVKEQFHG

Download         Length: 312 bp

>T143447 NZ_CP061101:1828719-1828970 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10119.58 Da        Isoelectric Point: 8.6582

>AT143447 WP_154320211.1 NZ_CP046045:c207923-207651 [Acinetobacter towneri]
MDNNLFDDLVASIKEAGAIKRKEVKAGRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp

>AT143447 NZ_CP061101:1828967-1829221 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References