Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
Location | 3646683..3647377 | Replicon | chromosome |
Accession | NZ_CP046025 | ||
Organism | Escherichia coli strain C439 |
Toxin (Protein)
Gene name | yafO | Uniprot ID | Q47157 |
Locus tag | GJH08_RS17815 | Protein ID | WP_001263489.1 |
Coordinates | 3646683..3647081 (-) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | yafN | Uniprot ID | S1QAE3 |
Locus tag | GJH08_RS17820 | Protein ID | WP_000554758.1 |
Coordinates | 3647084..3647377 (-) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
- | 3642271..3642351 | - | 81 | NuclAT_12 | - | - |
- | 3642271..3642351 | - | 81 | NuclAT_12 | - | - |
- | 3642271..3642351 | - | 81 | NuclAT_12 | - | - |
- | 3642271..3642351 | - | 81 | NuclAT_12 | - | - |
GJH08_RS17790 | 3642947..3643405 | - | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
GJH08_RS17795 | 3643666..3645123 | + | 1458 | WP_001292994.1 | cytosol nonspecific dipeptidase | - |
GJH08_RS17800 | 3645180..3645701 | - | 522 | Protein_3479 | peptide chain release factor H | - |
GJH08_RS17805 | 3645697..3645903 | - | 207 | Protein_3480 | RtcB family protein | - |
GJH08_RS17810 | 3646221..3646673 | - | 453 | WP_001059892.1 | GNAT family N-acetyltransferase | - |
GJH08_RS17815 | 3646683..3647081 | - | 399 | WP_001263489.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
GJH08_RS17820 | 3647084..3647377 | - | 294 | WP_000554758.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
GJH08_RS17825 | 3647429..3648484 | - | 1056 | WP_001226164.1 | DNA polymerase IV | - |
GJH08_RS17830 | 3648555..3649340 | - | 786 | WP_000207552.1 | putative lateral flagellar export/assembly protein LafU | - |
GJH08_RS17835 | 3649312..3651024 | + | 1713 | Protein_3486 | flagellar biosynthesis protein FlhA | - |
GJH08_RS17840 | 3651248..3651745 | - | 498 | WP_000006255.1 | REP-associated tyrosine transposase RayT | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15487.84 Da Isoelectric Point: 7.4215
>T143419 WP_001263489.1 NZ_CP046025:c3647081-3646683 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T143419 NZ_CP061082:2116564-2116660 [Serratia liquefaciens]
AACAAGCCTTGCACAAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT
AACAAGCCTTGCACAAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT
Antitoxin
Download Length: 98 a.a. Molecular weight: 11233.76 Da Isoelectric Point: 5.2170
>AT143419 WP_000554758.1 NZ_CP046025:c3647377-3647084 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT143419 NZ_CP061082:c2116665-2116542 [Serratia liquefaciens]
AACACAAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTTTGTGCAAGGCTTGTTCAGCCATGCACTTTAAGAGTAG
AACACAAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTTTGTGCAAGGCTTGTTCAGCCATGCACTTTAAGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A090J8B1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | S1QAE3 |