143404

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1794526..1795028 Replicon chromosome
Accession NZ_CP046025
Organism Escherichia coli strain C439

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag GJH08_RS08465 Protein ID WP_000767829.1
Coordinates 1794774..1795028 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag GJH08_RS08460 Protein ID WP_001259255.1
Coordinates 1794526..1794777 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJH08_RS08435 1789704..1790771 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
GJH08_RS08440 1790771..1791841 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
GJH08_RS08445 1791838..1793142 - 1305 WP_000009594.1 histidinol dehydrogenase -
GJH08_RS08450 1793148..1794047 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
GJH08_RS08455 1794193..1794243 - 51 WP_001364200.1 his operon leader peptide -
GJH08_RS08460 1794526..1794777 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
GJH08_RS08465 1794774..1795028 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
GJH08_RS08470 1795111..1795935 + 825 WP_000754737.1 SDR family oxidoreductase -
GJH08_RS08475 1795981..1796910 + 930 WP_000803351.1 LysR family transcriptional regulator -
GJH08_RS08480 1797125..1797187 + 63 WP_010723108.1 membrane protein YoeI -
GJH08_RS08485 1797177..1798535 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
GJH08_RS08490 1798714..1799772 + 1059 WP_000492339.1 transport protein YeeE -
GJH08_RS08495 1799786..1800013 + 228 WP_000234896.1 sulfurtransferase TusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T143404 WP_000767829.1 NZ_CP046025:1794774-1795028 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T143404 NZ_CP061081:c1758642-1758373 [Marinomonas arctica]
ATGTATCAGCTTGTATATTCAACACAATTCAAAAAAGATTTTAAGAAAATCACCAAAATGCCCATTGCCGACATCATTGA
AGTTGGGAATATCATTTCCCGCCTACAGCGCGGAGAAAGCTTAGATACTAAGCACGTAAATCATCCACTAACAGGAAATT
GGCTCGGATTCAAAGACTGCCATATAAAACCGGATTTGGTTCTTATTTACAGAGTAATAGATAACGCCTTACAACTGGCT
AGAATTGGATCTCATAGTGACGTTTTTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT143404 WP_001259255.1 NZ_CP046025:1794526-1794777 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT143404 NZ_CP061081:c1758915-1758649 [Marinomonas arctica]
ATGAAGAACGAAATGCTCAGTACTCGTATAGATCACGAAACTAAAGCCGCGTTTACACACATCTGTGATGAAGTCGGTTT
AAGCCCTTCACAAGCCATTAAGCTGTTTGCGAAAGCCGTTATCAACCACGGCGGAATTCCGTTTGATATAAAAATGCGTC
AACCAAATACAGACACCATCGCCGCAATGAAAGAGCTGAATCAAGGCCAAGGACATAAGGCCGAATCCGTCAGCAGCATG
TTTGAGGAATTAACAGAGGCAAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References