Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 654545..655272 | Replicon | chromosome |
Accession | NZ_CP046025 | ||
Organism | Escherichia coli strain C439 |
Toxin (Protein)
Gene name | higB | Uniprot ID | U9ZMR4 |
Locus tag | GJH08_RS03165 | Protein ID | WP_000550189.1 |
Coordinates | 654545..654859 (+) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | GJH08_RS03170 | Protein ID | WP_000560266.1 |
Coordinates | 654856..655272 (+) | Length | 139 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GJH08_RS03145 | 650703..651689 | - | 987 | WP_000617698.1 | Gfo/Idh/MocA family oxidoreductase | - |
GJH08_RS03150 | 651768..652460 | - | 693 | WP_000942548.1 | vancomycin high temperature exclusion protein | - |
GJH08_RS03155 | 652537..653040 | - | 504 | WP_001333820.1 | M48 family metallopeptidase | - |
GJH08_RS03160 | 653125..654261 | + | 1137 | WP_000018695.1 | 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG | - |
GJH08_RS03165 | 654545..654859 | + | 315 | WP_000550189.1 | type II toxin-antitoxin system toxin HigB | Toxin |
GJH08_RS03170 | 654856..655272 | + | 417 | WP_000560266.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
GJH08_RS03175 | 655317..657335 | - | 2019 | WP_000121433.1 | NADPH-dependent 2,4-dienoyl-CoA reductase | - |
GJH08_RS03180 | 657761..660112 | - | 2352 | WP_000695487.1 | alpha-glucosidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12103.10 Da Isoelectric Point: 10.0409
>T143398 WP_000550189.1 NZ_CP046025:654545-654859 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
Download Length: 315 bp
>T143398 NZ_CP061080:5282804-5283229 [Mesirhizobium sp. NIBR3]
TTGAACTATCTGCTGGACACCAACGTCCTGTCGGAATCATCTCGGCCGCAGCCGTCGCCCGACGTCATGCGATGGCTTGC
CGAGCTGGACGAGGACCGCGGCTTCGTAAGCGTCATCACGGTCGCCGAACTGCGTCGCGGAGCGTTGATTCTCGCGCCGG
GACGTCGCCGCGACTCGCTCATGTCCTGGATCGACGGGGAACTGCGGGACCGGTTCGCGGGCCGGATCATTCCCGTCGAC
GCCGAGGTGGCCGATCGCTGGTCCGATATCATGGTTGCCCGCCGTTCCGAAGGCCGTGGGCTCGGCGTCATGGACGGGTT
CCTGGCAGCGACGGCGCTCGTTCGCGGTTTGACGGTCGTGACGAGAAACATCCGTGATTTCGCCTTTCTGGGGGACCGTG
TCGTCAACCCGTGGGGAACCCCGTGA
TTGAACTATCTGCTGGACACCAACGTCCTGTCGGAATCATCTCGGCCGCAGCCGTCGCCCGACGTCATGCGATGGCTTGC
CGAGCTGGACGAGGACCGCGGCTTCGTAAGCGTCATCACGGTCGCCGAACTGCGTCGCGGAGCGTTGATTCTCGCGCCGG
GACGTCGCCGCGACTCGCTCATGTCCTGGATCGACGGGGAACTGCGGGACCGGTTCGCGGGCCGGATCATTCCCGTCGAC
GCCGAGGTGGCCGATCGCTGGTCCGATATCATGGTTGCCCGCCGTTCCGAAGGCCGTGGGCTCGGCGTCATGGACGGGTT
CCTGGCAGCGACGGCGCTCGTTCGCGGTTTGACGGTCGTGACGAGAAACATCCGTGATTTCGCCTTTCTGGGGGACCGTG
TCGTCAACCCGTGGGGAACCCCGTGA
Antitoxin
Download Length: 139 a.a. Molecular weight: 14995.42 Da Isoelectric Point: 4.4547
>AT143398 WP_000560266.1 NZ_CP046025:654856-655272 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
Download Length: 417 bp
>AT143398 NZ_CP061080:5282538-5282807 [Mesirhizobium sp. NIBR3]
GTGAGCAAGTCTGCGAACAAGGATCTGGACGTCTGGACGCTGGCCAATGCCAAGGCCCGCCTGTCGGAAGTCGTGGATCG
CGCGCAGGACGTTCCACAGATGGTCACCCGGAACGGCAGACCCGCGGTGGTGATCGTCTCGGCCGAAGAATGGAAGCGGA
AGACGGACCGGAAGGGCAACCTGGCCGAGTTCCTTCTTGCCTCGCCGCTCCGGGGGCTCGATCTCGACGTCGAGCGCGTG
GACGAACCGCCTCGCGAACTCGACCTTTGA
GTGAGCAAGTCTGCGAACAAGGATCTGGACGTCTGGACGCTGGCCAATGCCAAGGCCCGCCTGTCGGAAGTCGTGGATCG
CGCGCAGGACGTTCCACAGATGGTCACCCGGAACGGCAGACCCGCGGTGGTGATCGTCTCGGCCGAAGAATGGAAGCGGA
AGACGGACCGGAAGGGCAACCTGGCCGAGTTCCTTCTTGCCTCGCCGCTCCGGGGGCTCGATCTCGACGTCGAGCGCGTG
GACGAACCGCCTCGCGAACTCGACCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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