Detailed information of TA system TA143395

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 184866..185088
• Replicon: chromosome
• Accession: NZ_CP046025
• Organism: Escherichia coli strain C439

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: GJH08_RS00870
• Protein ID: WP_000141634.1
• Coordinates: 184981..185088 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	184866..184932 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJH08_RS00850	180307..181209	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
GJH08_RS00855	181220..182203	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
GJH08_RS00860	182200..183204	+	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
GJH08_RS00865	183234..184505	-	1272	WP_001295225.1	transporter	-
-	184866..184932	-	67	-	-	Antitoxin
GJH08_RS00870	184981..185088	+	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
GJH08_RS00875	185175..186854	-	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
GJH08_RS00880	186851..187042	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
GJH08_RS00885	187039..188610	-	1572	WP_001204931.1	cellulose biosynthesis protein BcsE	-
GJH08_RS00890	188883..189071	+	189	WP_001063318.1	YhjR family protein	-
GJH08_RS00895	189083..189835	+	753	Protein_175	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T143395 WP_000141634.1 NZ_CP046025:184981-185088 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T143395 NZ_CP061080:3667949-3668353 [Mesirhizobium sp. NIBR3]
ATGATGCTCTACCTGCTGGATACCAATGCGGTGAGCATGGCCGTCCATCGCCGCTCCTCGGCCCTCGACCGCCGGATGGA
TCAGATCGGCGTAGATGCGATCGCAATATCGTCGATCACCTACGGTGAGATCGTCTACGGCCTCGAGTGGAAAGCGGAGG
CTCGCAGGCTTGCGAGGAGCATGGGAGATTTCCTTCGGGAGATCATGGTCCTGCCGTGGACCGAAGCGACTGGCGATCTC
TACGGCAAGCTGCGTGCCGATATGCGCCGCAGCGGCATCTCCCTCCAGCCCCTCGACCTCCTCATCGCCGCGCACGCGCT
GGAGGCGGGCGCCACGCTCGTCACCAGCGATGTCGCCTTCCGCCACGTGCCCGGGCTGACCGTCGAGGACTGGACGGTGC
CCTGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT143395 NZ_CP046025:c184932-184866 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin