Detailed information of TA system TA143385

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1705358..1705847
• Replicon: chromosome
• Accession: NZ_CP046022
• Organism: Enterococcus faecalis strain BFF1B1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: GIO26_RS08025
• Protein ID: WP_002386265.1
• Coordinates: 1705719..1705847 (+)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1705358..1705537 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GIO26_RS08000	1700436..1700834	+	399	WP_002354951.1	glyoxalase	-
GIO26_RS08005	1700885..1701781	-	897	WP_002365354.1	YitT family protein	-
GIO26_RS08010	1702180..1702680	-	501	WP_002365352.1	cysteine hydrolase	-
GIO26_RS08015	1702851..1705121	+	2271	WP_033592304.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
GIO26_RS08020	1705284..1705413	+	130	Protein_1565	putative holin-like toxin	-
-	1705358..1705537	-	180	-	-	Antitoxin
GIO26_RS08025	1705719..1705847	+	129	WP_002386265.1	hypothetical protein	Toxin
GIO26_RS08030	1706029..1706481	-	453	WP_002359057.1	YueI family protein	-
GIO26_RS08035	1706666..1707613	+	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
GIO26_RS08040	1707610..1708575	+	966	WP_002367415.1	iron chelate uptake ABC transporter family permease subunit	-
GIO26_RS08045	1708572..1709327	+	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
GIO26_RS08050	1709366..1710319	+	954	WP_163402745.1	siderophore ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4742.66 Da
• Isoelectric Point: 7.0058

>T143385 WP_002386265.1 NZ_CP046022:1705719-1705847 [Enterococcus faecalis]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 129 bp

>T143385 NZ_CP061079:4349838-4350188 [Pseudomonas chlororaphis]
ATGGACGCACTTTTTATTGAGCTGCCCCCGTTCCAACGCCATCGACAGGACTACCTGGACGACGAGCTTTTTCGTAGCTT
GCAGCTTGAGTTGCTGAAAGCCCCCGAAGCCGGAGATCTCATCGAGGGAACCGATGGCTTGCGCAAGATCCGCTTTGTCG
ATGAGCGACGGCACAAGGGCAAACGCGGCGGGATCCGGGTGATTTATTACTGGTGGTCCGGAGGCGCCCAACTCTGGCTC
TTCACCCTTTACGCAAAGAACGAGCTGAACGACCTGACACCCCATCAGAAAAAACTGCTCAAGCAACTGCTGAACAGAGA
AGTCGAGGCGAGAACCCATCATGAAACGTGA

Antitoxin

Nucleotide

• Length: 180 bp

>AT143385 NZ_CP046022:c1705537-1705358 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Structures

Antitoxin