Detailed information of TA system TA143382

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1640705..1640977
• Replicon: chromosome
• Accession: NZ_CP046022
• Organism: Enterococcus faecalis strain BFF1B1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A2P6B8G0
• Locus tag: GIO26_RS07720
• Protein ID: WP_002354873.1
• Coordinates: 1640705..1640857 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1640790..1640977 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GIO26_RS07700	1637105..1637659	+	555	WP_002396824.1	septum formation protein Maf	-
GIO26_RS07705	1637792..1638229	+	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
GIO26_RS07710	1638404..1639375	+	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
GIO26_RS07715	1639428..1639961	-	534	WP_081115787.1	CPBP family intramembrane metalloprotease	-
GIO26_RS07720	1640705..1640857	+	153	WP_002354873.1	putative holin-like toxin	Toxin
-	1640790..1640977	-	188	-	-	Antitoxin
GIO26_RS07725	1641098..1641691	-	594	WP_163402572.1	hypothetical protein	-
GIO26_RS07730	1642106..1642756	-	651	WP_081115788.1	beta-phosphoglucomutase	-
GIO26_RS07735	1642771..1645515	-	2745	WP_163402574.1	glycoside hydrolase family 65 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (17-50)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5651.89 Da
• Isoelectric Point: 10.9857

>T143382 WP_002354873.1 NZ_CP046022:1640705-1640857 [Enterococcus faecalis]
VVRMSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 153 bp

>T143382 NZ_CP061079:c2296498-2296316 [Pseudomonas chlororaphis]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCGCAGGCTGGGTGCTGGAGCGCGTTACCGGCAGCCATCATCTGTT
CAAGCATCCCTATCGGCCCGAGACCGTTCCGGTGCCTCACCCGAAGAAGGATCTGCCACGGGGGACGGTCAGGGCCATCC
AGAAACTGGCCGGGCTGATATAG

Antitoxin

Nucleotide

• Length: 188 bp

>AT143382 NZ_CP046022:c1640977-1640790 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGT
GCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A2P6B8G0

Antitoxin