Detailed information of TA system TA143378

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1551042..1551325
• Replicon: chromosome
• Accession: NZ_CP046022
• Organism: Enterococcus faecalis strain BFF1B1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: GIO26_RS07285
• Protein ID: WP_002411240.1
• Coordinates: 1551176..1551325 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1551042..1551243 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GIO26_RS07280	1550740..1550883	-	144	WP_002396786.1	putative holin-like toxin	-
-	1551042..1551243	+	202	-	-	Antitoxin
GIO26_RS07285	1551176..1551325	-	150	WP_002411240.1	putative holin-like toxin	Toxin
GIO26_RS07290	1551654..1553270	-	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
GIO26_RS07295	1553732..1555027	+	1296	WP_010820355.1	AAA family ATPase	-
GIO26_RS07300	1555036..1555668	+	633	WP_207578862.1	RloB domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (16-49)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5738.05 Da
• Isoelectric Point: 11.3858

>T143378 WP_002411240.1 NZ_CP046022:c1551325-1551176 [Enterococcus faecalis]
MRMHVFPKFRERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 150 bp

>T143378 NZ_CP061074:c58922-58572 [Pseudomonas aeruginosa]
ATGAGCAAACGCCTGCAGCATCAGTTCGACCGCGGCGATATCGTCTCCTTGGACATGGGTAGCGCTTCAGCACAGGCGGC
CTGCAAAGCGCTCGTGCTTTCCCCTGCAGCGTACAACGTCCTGGGGCTCGCCCTAGCCATTCCTATCACCGAGCACGACA
GCAGCCGCTACGCCGGCTTTGCCGTCGCGATCCTCCTTCCAGGGCGCACGCCGGCGAAGGGGGCAGCCTTGGTCAACCTG
GTGCGGCCGGTGGATCTTGCTGCAAGAGGTGCAAAGCTGCTCGGGAAGGCGCCCCAGACGACCATAGATGAAGCCCTGCA
GCGCCTGCAGGCGGTTGTTGGGAAAGACTGA

Antitoxin

Nucleotide

• Length: 202 bp

>AT143378 NZ_CP046022:1551042-1551243 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTGTAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTAGTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin