Detailed information of TA system TA143375

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1550740..1551243
• Replicon: chromosome
• Accession: NZ_CP046022
• Organism: Enterococcus faecalis strain BFF1B1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: GIO26_RS07280
• Protein ID: WP_002396786.1
• Coordinates: 1550740..1550883 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1551042..1551243 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GIO26_RS07275	1545854..1550545	+	4692	WP_081115773.1	WxL domain-containing protein	-
GIO26_RS07280	1550740..1550883	-	144	WP_002396786.1	putative holin-like toxin	Toxin
-	1551042..1551243	+	202	-	-	Antitoxin
GIO26_RS07285	1551176..1551325	-	150	WP_002411240.1	putative holin-like toxin	-
GIO26_RS07290	1551654..1553270	-	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
GIO26_RS07295	1553732..1555027	+	1296	WP_010820355.1	AAA family ATPase	-
GIO26_RS07300	1555036..1555668	+	633	WP_207578862.1	RloB domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T143375 WP_002396786.1 NZ_CP046022:c1550883-1550740 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T143375 NZ_CP061073:c3385076-3384795 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA

Antitoxin

Nucleotide

• Length: 202 bp

>AT143375 NZ_CP046022:1551042-1551243 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTGTAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTAGTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin