Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 725844..726537 Replicon chromosome
Accession NZ_CP046006
Organism Escherichia coli strain 1919D3

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag GJD95_RS05185 Protein ID WP_000415584.1
Coordinates 725844..726140 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag GJD95_RS05190 Protein ID WP_000650107.1
Coordinates 726142..726537 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJD95_RS05150 720932..721246 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
GJD95_RS05155 721277..721858 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
GJD95_RS05160 722177..722509 + 333 WP_000912120.1 DUF2645 family protein -
GJD95_RS05165 722555..723904 - 1350 WP_000673355.1 two-component system sensor histidine kinase QseC -
GJD95_RS05170 723901..724560 - 660 WP_001221502.1 two-component system response regulator QseB -
GJD95_RS05175 724712..725104 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
GJD95_RS05180 725157..725639 + 483 WP_000183494.1 transcriptional regulator -
GJD95_RS05185 725844..726140 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
GJD95_RS05190 726142..726537 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
GJD95_RS05195 726670..728277 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
GJD95_RS05200 728415..730673 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T143323 WP_000415584.1 NZ_CP046006:725844-726140 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T143323 NZ_CP061034:c2451584-2451405 [Pseudomonas aeruginosa]
ATGAAGTTCAGCGAATTCCGACGCTGGCTGAGGGCACAAGGCGTGTCCTTCGAAGCTGGCAAGGGCAGTCACTTCAAGGT
GACCGCCCCGAACGGTAAGACAACGACCTTCGCAGATCACGGCGCCAAGGAAATGCCGGAGCCGACACGCAAGGCGATCA
TCAAGCAACTGGGGCTCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT143323 WP_000650107.1 NZ_CP046006:726142-726537 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT143323 NZ_CP061034:c2451365-2450790 [Pseudomonas aeruginosa]
ATGTACAACTTCGCAATCCGTTTCGAGCAGGACGACAGCGCTCCTGGCGTTGCCGTTTTCTGTCGAGACCTTCCAGAACT
GAACAGCTATGGAGACACCGTCGAGCACGCGCTCAGCGAGGCCGTTGATGCCATCGAAACCACATTGTCGCTATACGTTG
ATCAACGCCGATCAATTCCAGTGGCTAGCGCTCCAGAGCCAGAAGAGCATGTCGTACATCTTCCGGCTGTGACCGTCGCA
AAGATCGCTCTATGGAATGAGATGATGAGGCGAGGCATGAGGAAGGCAGATCTATGCCGGGTGCTTGGTATCGCCCAAGT
GCAGGGAGATCGTCTTGTCGACTTCTTGCATACATCGAAAATGGAGCAGGTCGAAAGCGCACTGGCCGCACTTGAAATGC
GCCTTGTGATTTGCGCCGAGCCAGTCAAGCAACCGAAGCAGTGCAAGGGCGCAGGGTGTATTCGAGATCGGCGACTCGTT
AAAGCACGCCGCCTGCTGCGCGCCCGGCTCCTTGAACTAACAGAATCTAGCGGCGCGTTCACGCGCGCTCCCAAAATCAA
AAAGCCCGGCATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References