143314

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3744227..3744768 Replicon chromosome
Accession NZ_CP046003
Organism Escherichia coli strain 1916D6

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag GJD94_RS18975 Protein ID WP_000615983.1
Coordinates 3744490..3744768 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag GJD94_RS18970 Protein ID WP_000729703.1
Coordinates 3744227..3744487 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJD94_RS18950 3739902..3740687 - 786 WP_000207587.1 putative lateral flagellar export/assembly protein LafU -
GJD94_RS18955 3740659..3742371 + 1713 Protein_3564 flagellar biosynthesis protein FlhA -
GJD94_RS18960 3742595..3743092 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
GJD94_RS18965 3743268..3744017 - 750 WP_024192679.1 C40 family peptidase -
GJD94_RS18970 3744227..3744487 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
GJD94_RS18975 3744490..3744768 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
GJD94_RS18980 3744924..3745664 + 741 WP_001225679.1 murein L,D-transpeptidase -
GJD94_RS18985 3745635..3746402 - 768 WP_000333380.1 class II glutamine amidotransferase -
GJD94_RS18990 3746608..3747186 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T143314 WP_000615983.1 NZ_CP046003:3744490-3744768 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T143314 NZ_CP061030:c947698-947384 [Staphylococcus pseudintermedius]
ATGGGTAATTATTCTGTCTTAATTAAGAATTCAGCCAAAAATGACTTGAAAAAAATTAAAAAGTCACTTCTTAAAGAGCA
ATTTTCAAAAATTATTGAAGTTTTAAAGATTAACCCTTATGAAGCTAGTCAATCTTTTGAGAAGCTACAACCGAAGCATT
CAGCTCGATATTCAAGGCGTCTGAATCATCAACATAGAGTTGTGTATACGGTTGATGATGAAAAAAGAGAAGTTTATATT
TTTCTGCTTGGTCATATTATGAGTGAGCGATATGTAAATAAGTGCTGTGAAAGCATTGATAGTGAGTTATATTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT143314 WP_000729703.1 NZ_CP046003:3744227-3744487 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT143314 NZ_CP061030:c947955-947698 [Staphylococcus pseudintermedius]
ATGATTATTAAAACGCCTACAAATGCTAGAAAAGAGTTTTACGAGTTGTTAAAACAAGTTAATGATAATCATGAGCCTAT
TATAATAAGTGGTTCTAAAAGTGAAAACAATGCAGTTATTGTTAGTCAGGAAGACTGGGATAGTATTCAAGAAACGTTAT
TTCTCGAATACACTGGTACTATGGATAAAGTAAGAGCACGTGAAAAAGATGATAGTGGTTATACCAATATTGACGATATA
GATTGGGATAATTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
AlphaFold DB A0A5F1F716

References