Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
Location | 2508204..2508842 | Replicon | chromosome |
Accession | NZ_CP046003 | ||
Organism | Escherichia coli strain 1916D6 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | S1F9G9 |
Locus tag | GJD94_RS12895 | Protein ID | WP_000813794.1 |
Coordinates | 2508666..2508842 (-) | Length | 59 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | - |
Locus tag | GJD94_RS12890 | Protein ID | WP_001270286.1 |
Coordinates | 2508204..2508620 (-) | Length | 139 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GJD94_RS12870 | 2503356..2504297 | - | 942 | WP_001251304.1 | ABC transporter permease | - |
GJD94_RS12875 | 2504298..2505311 | - | 1014 | WP_000220396.1 | ABC transporter ATP-binding protein | - |
GJD94_RS12880 | 2505329..2506474 | - | 1146 | WP_000047424.1 | ABC transporter substrate-binding protein | - |
GJD94_RS12885 | 2506719..2508125 | - | 1407 | WP_000760626.1 | PLP-dependent aminotransferase family protein | - |
GJD94_RS12890 | 2508204..2508620 | - | 417 | WP_001270286.1 | type II toxin-antitoxin system antitoxin HicB | Antitoxin |
GJD94_RS12895 | 2508666..2508842 | - | 177 | WP_000813794.1 | type II toxin-antitoxin system mRNA interferase toxin HicA | Toxin |
GJD94_RS12900 | 2509064..2509294 | + | 231 | WP_000494244.1 | YncJ family protein | - |
GJD94_RS12905 | 2509386..2511347 | - | 1962 | WP_001303492.1 | 23S rRNA 5-hydroxycytidine C2501 synthase | - |
GJD94_RS12910 | 2511420..2511956 | - | 537 | WP_000429155.1 | DNA-binding transcriptional regulator SutR | - |
GJD94_RS12915 | 2512009..2513223 | + | 1215 | WP_074400818.1 | BenE family transporter YdcO | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 2513263..2514411 | 1148 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6749.83 Da Isoelectric Point: 11.2298
>T143311 WP_000813794.1 NZ_CP046003:c2508842-2508666 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS
Download Length: 177 bp
>T143311 NZ_CP061029:2273318-2273413 [Staphylococcus epidermidis]
ATGGCAGATATTCTTGTTAATATCATGACCACGGCAGCAAGTGGTTGTATCGTCGCGTTGTTTTCATATTGGCTTCGAAA
ACGTGATGATAAATAG
ATGGCAGATATTCTTGTTAATATCATGACCACGGCAGCAAGTGGTTGTATCGTCGCGTTGTTTTCATATTGGCTTCGAAA
ACGTGATGATAAATAG
Antitoxin
Download Length: 139 a.a. Molecular weight: 15246.63 Da Isoelectric Point: 4.7386
>AT143311 WP_001270286.1 NZ_CP046003:c2508620-2508204 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
Download Length: 417 bp
>AT143311 NZ_CP061029:c2273474-2273438 [Staphylococcus epidermidis]
ATGCACCAATCCCCTCACTACTGCCATAGTGAGGGGA
ATGCACCAATCCCCTCACTACTGCCATAGTGAGGGGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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