Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3356601..3357396 Replicon chromosome
Accession NZ_CP045975
Organism Escherichia coli strain AUSMDU00002545

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag GJD97_RS17315 Protein ID WP_000854914.1
Coordinates 3356601..3356975 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag GJD97_RS17320 Protein ID WP_001280954.1
Coordinates 3357022..3357396 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJD97_RS17275 3351605..3352096 - 492 WP_001301587.1 DUF1097 domain-containing protein -
GJD97_RS17280 3352198..3352752 - 555 WP_001001917.1 molecular chaperone YcdY -
GJD97_RS17285 3352776..3353513 - 738 WP_000283664.1 zinc-binding phosphatase -
GJD97_RS17290 3353568..3354506 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
GJD97_RS17300 3354977..3355819 - 843 WP_001280481.1 DUF4942 domain-containing protein -
GJD97_RS17305 3355904..3356101 - 198 WP_000839282.1 DUF957 domain-containing protein -
GJD97_RS17310 3356113..3356604 - 492 WP_000976853.1 hypothetical protein -
GJD97_RS17315 3356601..3356975 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
GJD97_RS17320 3357022..3357396 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GJD97_RS17325 3357559..3357780 - 222 WP_001220314.1 DUF987 domain-containing protein -
GJD97_RS17330 3357843..3358319 - 477 WP_001186738.1 RadC family protein -
GJD97_RS17335 3358335..3358820 - 486 WP_000214398.1 antirestriction protein -
GJD97_RS17340 3358911..3359729 - 819 WP_001234682.1 DUF945 domain-containing protein -
GJD97_RS17345 3360069..3361139 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
GJD97_RS17350 3361136..3362041 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 3347987..3358820 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T143198 WP_000854914.1 NZ_CP045975:c3356975-3356601 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T143198 NZ_CP060969:799804-800100 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT143198 WP_001280954.1 NZ_CP045975:c3357396-3357022 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT143198 NZ_CP060969:800102-800497 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References