Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 651605..652404 Replicon chromosome
Accession NZ_CP045975
Organism Escherichia coli strain AUSMDU00002545

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag GJD97_RS03205 Protein ID WP_000347273.1
Coordinates 651605..652069 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID C3ST72
Locus tag GJD97_RS03210 Protein ID WP_001302819.1
Coordinates 652069..652404 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJD97_RS03175 646606..647040 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
GJD97_RS03180 647058..647936 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
GJD97_RS03185 647926..648705 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
GJD97_RS03190 648716..649189 - 474 WP_001301475.1 PTS N-acetylgalactosamine transporter subunit IIB -
GJD97_RS03195 649212..650492 - 1281 WP_000681927.1 tagatose-bisphosphate aldolase subunit KbaZ -
GJD97_RS03200 650741..651550 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
GJD97_RS03205 651605..652069 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
GJD97_RS03210 652069..652404 - 336 WP_001302819.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
GJD97_RS03215 652553..654124 - 1572 WP_001273776.1 galactarate dehydratase -
GJD97_RS03220 654499..655848 + 1350 WP_023352333.1 galactarate/glucarate/glycerate transporter GarP -
GJD97_RS03225 655864..656634 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T143184 WP_000347273.1 NZ_CP045975:c652069-651605 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T143184 NZ_CP060963:2712556-2712663 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12388.97 Da        Isoelectric Point: 4.8616

>AT143184 WP_001302819.1 NZ_CP045975:c652404-652069 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDTDIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT143184 NZ_CP060963:c2712509-2712443 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure

References