Detailed information of TA system TA143102

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 713310..713907
• Replicon: chromosome
• Accession: NZ_CP045961
• Organism: Neisseria meningitidis strain AUSMDU00010537

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: GJE04_RS03930
• Protein ID: WP_002242826.1
• Coordinates: 713629..713907 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: GJE04_RS03925
• Protein ID: WP_002221020.1
• Coordinates: 713310..713621 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJE04_RS03905	709203..709367	+	165	WP_002224559.1	baseplate J/gp47 family protein	-
GJE04_RS03910	709367..709978	+	612	WP_042744707.1	baseplate J/gp47 family protein	-
GJE04_RS03915	709975..710535	+	561	WP_002213590.1	YmfQ family protein	-
GJE04_RS03920	710546..712519	+	1974	WP_002248050.1	pyocin knob domain-containing protein	-
GJE04_RS03925	713310..713621	-	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
GJE04_RS03930	713629..713907	-	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GJE04_RS03935	713992..714597	+	606	WP_002219301.1	hypothetical protein	-
GJE04_RS03940	714576..714872	+	297	WP_002221017.1	hypothetical protein	-
GJE04_RS03945	714869..715078	+	210	WP_002222487.1	hypothetical protein	-
GJE04_RS03950	715188..716331	-	1144	Protein_735	ABC transporter ATP-binding protein/permease	-
GJE04_RS03960	716620..717267	-	648	WP_002217218.1	DUF799 domain-containing protein	-
GJE04_RS03965	717264..717632	-	369	WP_002234874.1	DUF4810 domain-containing protein	-
GJE04_RS03970	717642..718313	-	672	WP_002217215.1	CsgG/HfaB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	701321..714872	13551
	-	flank	IS/Tn	-	-	708173..709138	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T143102 WP_002242826.1 NZ_CP045961:c713907-713629 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T143102 NZ_CP060946:c1635670-1635272 [Escherichia coli O157:H7 str. EC10]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT143102 WP_002221020.1 NZ_CP045961:c713621-713310 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT143102 NZ_CP060946:c1635897-1635670 [Escherichia coli O157:H7 str. EC10]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6