Detailed information of TA system TA143004

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): bsrE-as-bsrE/-
• Location: 2069405..2069720
• Replicon: chromosome
• Accession: NZ_CP045922
• Organism: Bacillus subtilis strain P8_B1

Toxin (Protein)

• Gene name: bsrE
• Uniprot ID: -
• Locus tag: GII87_RS10340
• Protein ID: WP_120322743.1
• Coordinates: 2069405..2069566 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	as-bsrE
Locus tag	-
Coordinates	2069547..2069720 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GII87_RS10325	2064633..2064968	+	336	WP_009967409.1	hypothetical protein	-
GII87_RS10330	2065015..2068620	-	3606	WP_004399367.1	membrane protein	-
GII87_RS10335	2068853..2069185	-	333	WP_026009814.1	hypothetical protein	-
GII87_RS10340	2069405..2069566	+	162	WP_120322743.1	putative holin-like toxin	Toxin
-	2069547..2069720	-	174	-	-	Antitoxin
GII87_RS10345	2069835..2070677	-	843	WP_003231327.1	hypothetical protein	-
GII87_RS10350	2070877..2071335	-	459	WP_003231326.1	type II toxin-antitoxin system antitoxin YobK	-
GII87_RS10355	2071345..2073147	-	1803	WP_004399481.1	type II toxin-antitoxin system toxin ribonuclease YobL	-
GII87_RS10360	2073249..2073806	-	558	WP_004399321.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2055459..2080685	25226

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (24-47)

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 5780.74 Da
• Isoelectric Point: 4.6641

>T143004 WP_120322743.1 NZ_CP045922:2069405-2069566 [Bacillus subtilis]
ISCTVSFAHSRESCSSPNERGDAMSTFQALMLMLAIGSFIIALLTYIEKIDLP

Nucleotide

• Length: 162 bp

>T143004 NZ_CP060924:1369445-1369843 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin

Nucleotide

• Length: 174 bp

>AT143004 NZ_CP045922:c2069720-2069547 [Bacillus subtilis]
TTACAATACATTACAGTGCATTTCTTTAATGAGAAATGCATAAAATAAAAAAGACCGAGGTGCTACCAACACCCCGGCTC
TGTACAAAAAGTTGCCCATCAAAGGGCTTGCTCGATGTGGTTCTAGGTAGGCCTATCCCTTCAGGTTCTGAGGCTCAAGG
GAGGTCTATTTTTT

Structures

Antitoxin