Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5737375..5737970 Replicon chromosome
Accession NZ_CP045916
Organism Pseudomonas aeruginosa strain CF39S

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag GIY05_RS26830 Protein ID WP_003113526.1
Coordinates 5737692..5737970 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GIY05_RS26825 Protein ID WP_003099268.1
Coordinates 5737375..5737680 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIY05_RS26790 5732514..5733362 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
GIY05_RS26800 5733529..5734470 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
GIY05_RS26805 5734587..5735201 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
GIY05_RS26810 5735243..5735827 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
GIY05_RS26815 5735868..5736968 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
GIY05_RS26825 5737375..5737680 - 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
GIY05_RS26830 5737692..5737970 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GIY05_RS26835 5738299..5740527 + 2229 WP_003099265.1 TonB-dependent receptor -
GIY05_RS26840 5740597..5741244 - 648 WP_003095021.1 carbonate dehydratase -
GIY05_RS26845 5741306..5742544 - 1239 WP_003099263.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T142988 WP_003113526.1 NZ_CP045916:c5737970-5737692 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T142988 NZ_CP060919:3015439-3015546 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT142988 WP_003099268.1 NZ_CP045916:c5737680-5737375 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT142988 NZ_CP060919:c3015391-3015324 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References