Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3380137..3380789 Replicon chromosome
Accession NZ_CP045913
Organism Serratia proteamaculans strain 336X

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GHV41_RS16125 Protein ID WP_153859245.1
Coordinates 3380445..3380789 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GHV41_RS16120 Protein ID WP_153859244.1
Coordinates 3380137..3380439 (-) Length 101 a.a.

Genomic Context

GHV41_RS16100GHV41_RS16105GHV41_RS16115GHV41_RS16135GHV41_RS16110GHV41_RS16120GHV41_RS16125GHV41_RS16130GHV41_RS16140
Location: 3375418..3376326 (909 bp)
Type: Others
Protein ID: WP_153859240.1
Location: 3376641..3377795 (1155 bp)
Type: Others
Protein ID: WP_153859241.1
Location: 3378841..3380103 (1263 bp)
Type: Others
Protein ID: WP_153859243.1
Location: 3382094..3382549 (456 bp)
Type: Others
Protein ID: WP_153859247.1
Location: 3377785..3378708 (924 bp)
Type: Others
Protein ID: WP_153859242.1
Location: 3380137..3380439 (303 bp)
Type: Antitoxin
Protein ID: WP_153859244.1
Location: 3380445..3380789 (345 bp)
Type: Toxin
Protein ID: WP_153859245.1
Location: 3380929..3381939 (1011 bp)
Type: Others
Protein ID: WP_153859246.1
Location: 3382546..3383565 (1020 bp)
Type: Others
Protein ID: WP_153859248.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GHV41_RS161003375418..3376326+909WP_153859240.1LysR family transcriptional regulator-
GHV41_RS161053376641..3377795+1155WP_153859241.1MFS transporter-
GHV41_RS161103377785..3378708-924WP_153859242.1LysR family transcriptional regulator-
GHV41_RS161153378841..3380103+1263WP_153859243.1diaminopimelate decarboxylase-
GHV41_RS161203380137..3380439-303WP_153859244.1helix-turn-helix transcriptional regulatorAntitoxin
GHV41_RS161253380445..3380789-345WP_153859245.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GHV41_RS161303380929..3381939-1011WP_153859246.1LacI family DNA-binding transcriptional regulator-
GHV41_RS161353382094..3382549+456WP_153859247.1GNAT family N-acetyltransferase-
GHV41_RS161403382546..3383565-1020WP_153859248.1HTH-type transcriptional regulator GalR-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(21-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13413.39 Da        Isoelectric Point: 9.7587

>T142978 WP_153859245.1 NZ_CP045913:c3380789-3380445 [Serratia proteamaculans]
MWQVVTVERFDNWFLSLNDDEQKSLLVGIFKLQEFGPLLARPHADTLHHNGQIQHLKELRIQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRLLPIAASEFPHYLATQR

Download         Length: 345 bp

>T142978 NZ_CP060919:931223-931606 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11153.08 Da        Isoelectric Point: 10.1425

>AT142978 WP_153859244.1 NZ_CP045913:c3380439-3380137 [Serratia proteamaculans]
MAKPLANLIEKLDPTVVEAARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLEVQLPNGQHRRMSL

Download         Length: 303 bp

>AT142978 NZ_CP060919:930765-931133 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References