Detailed information of TA system TA142978

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3380137..3380789
• Replicon: chromosome
• Accession: NZ_CP045913
• Organism: Serratia proteamaculans strain 336X

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: GHV41_RS16125
• Protein ID: WP_153859245.1
• Coordinates: 3380445..3380789 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: GHV41_RS16120
• Protein ID: WP_153859244.1
• Coordinates: 3380137..3380439 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GHV41_RS16100	3375418..3376326	+	909	WP_153859240.1	LysR family transcriptional regulator	-
GHV41_RS16105	3376641..3377795	+	1155	WP_153859241.1	MFS transporter	-
GHV41_RS16110	3377785..3378708	-	924	WP_153859242.1	LysR family transcriptional regulator	-
GHV41_RS16115	3378841..3380103	+	1263	WP_153859243.1	diaminopimelate decarboxylase	-
GHV41_RS16120	3380137..3380439	-	303	WP_153859244.1	helix-turn-helix transcriptional regulator	Antitoxin
GHV41_RS16125	3380445..3380789	-	345	WP_153859245.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GHV41_RS16130	3380929..3381939	-	1011	WP_153859246.1	LacI family DNA-binding transcriptional regulator	-
GHV41_RS16135	3382094..3382549	+	456	WP_153859247.1	GNAT family N-acetyltransferase	-
GHV41_RS16140	3382546..3383565	-	1020	WP_153859248.1	HTH-type transcriptional regulator GalR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-104)

Antitoxin

• HigA2-like, helix-turn-helix domain (21-89)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13413.39 Da
• Isoelectric Point: 9.7587

>T142978 WP_153859245.1 NZ_CP045913:c3380789-3380445 [Serratia proteamaculans]
MWQVVTVERFDNWFLSLNDDEQKSLLVGIFKLQEFGPLLARPHADTLHHNGQIQHLKELRIQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRLLPIAASEFPHYLATQR

Nucleotide

• Length: 345 bp

>T142978 NZ_CP060919:931223-931606 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11153.08 Da
• Isoelectric Point: 10.1425

>AT142978 WP_153859244.1 NZ_CP045913:c3380439-3380137 [Serratia proteamaculans]
MAKPLANLIEKLDPTVVEAARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLEVQLPNGQHRRMSL

Nucleotide

• Length: 303 bp

>AT142978 NZ_CP060919:930765-931133 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA