Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2286581..2287083 Replicon chromosome
Accession NZ_CP045913
Organism Serratia proteamaculans strain 336X

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag GHV41_RS11115 Protein ID WP_153858556.1
Coordinates 2286829..2287083 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag GHV41_RS11110 Protein ID WP_153858555.1
Coordinates 2286581..2286832 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHV41_RS11090 2281781..2281960 + 180 WP_167519921.1 ANR family transcriptional regulator -
GHV41_RS11095 2282072..2282422 + 351 WP_153858552.1 hypothetical protein -
GHV41_RS11100 2282591..2284417 - 1827 WP_153858553.1 hypothetical protein -
GHV41_RS11105 2285282..2285509 - 228 WP_153858554.1 hypothetical protein -
GHV41_RS26635 2285565..2285663 - 99 Protein_2161 heteromeric transposase endonuclease subunit TnsA -
GHV41_RS11110 2286581..2286832 + 252 WP_153858555.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
GHV41_RS11115 2286829..2287083 + 255 WP_153858556.1 Txe/YoeB family addiction module toxin Toxin
GHV41_RS11120 2287102..2287404 + 303 WP_153858557.1 hypothetical protein -
GHV41_RS11125 2287571..2287768 + 198 WP_153858558.1 hypothetical protein -
GHV41_RS11130 2288094..2288798 + 705 WP_153858559.1 IS6 family transposase -
GHV41_RS11135 2289303..2290127 + 825 WP_153858560.1 tyrosine-type recombinase/integrase -
GHV41_RS26725 2290278..2290898 - 621 WP_206194513.1 hypothetical protein -
GHV41_RS11145 2290975..2291253 + 279 WP_153858561.1 hypothetical protein -
GHV41_RS11150 2291363..2291620 - 258 WP_129937179.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2288094..2288798 704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10016.51 Da        Isoelectric Point: 7.8745

>T142972 WP_153858556.1 NZ_CP045913:2286829-2287083 [Serratia proteamaculans]
VKIVFAEQSWADYLYWQQTDKKMLKRVDELIREIQRSPMAGIGKPEPLKHNLSGFWSRRIDTEHRLVYQVTDDSLLIASC
CYHY

Download         Length: 255 bp

>T142972 NZ_CP060914:c4589123-4588773 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9358.61 Da        Isoelectric Point: 4.6258

>AT142972 WP_153858555.1 NZ_CP045913:2286581-2286832 [Serratia proteamaculans]
MKTLSFSEARQNFASVMNETFDDKAPILITRQKGTACVIMSLEEYESLEETAYLLRSPSNARHLMDSITELKSGRGLEKD
LAE

Download         Length: 252 bp

>AT142972 NZ_CP060914:c4589368-4589117 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References