Detailed information of TA system TA142972

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 2286581..2287083
• Replicon: chromosome
• Accession: NZ_CP045913
• Organism: Serratia proteamaculans strain 336X

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: GHV41_RS11115
• Protein ID: WP_153858556.1
• Coordinates: 2286829..2287083 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: GHV41_RS11110
• Protein ID: WP_153858555.1
• Coordinates: 2286581..2286832 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GHV41_RS11090	2281781..2281960	+	180	WP_167519921.1	ANR family transcriptional regulator	-
GHV41_RS11095	2282072..2282422	+	351	WP_153858552.1	hypothetical protein	-
GHV41_RS11100	2282591..2284417	-	1827	WP_153858553.1	hypothetical protein	-
GHV41_RS11105	2285282..2285509	-	228	WP_153858554.1	hypothetical protein	-
GHV41_RS26635	2285565..2285663	-	99	Protein_2161	heteromeric transposase endonuclease subunit TnsA	-
GHV41_RS11110	2286581..2286832	+	252	WP_153858555.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
GHV41_RS11115	2286829..2287083	+	255	WP_153858556.1	Txe/YoeB family addiction module toxin	Toxin
GHV41_RS11120	2287102..2287404	+	303	WP_153858557.1	hypothetical protein	-
GHV41_RS11125	2287571..2287768	+	198	WP_153858558.1	hypothetical protein	-
GHV41_RS11130	2288094..2288798	+	705	WP_153858559.1	IS6 family transposase	-
GHV41_RS11135	2289303..2290127	+	825	WP_153858560.1	tyrosine-type recombinase/integrase	-
GHV41_RS26725	2290278..2290898	-	621	WP_206194513.1	hypothetical protein	-
GHV41_RS11145	2290975..2291253	+	279	WP_153858561.1	hypothetical protein	-
GHV41_RS11150	2291363..2291620	-	258	WP_129937179.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2288094..2288798	704

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10016.51 Da
• Isoelectric Point: 7.8745

>T142972 WP_153858556.1 NZ_CP045913:2286829-2287083 [Serratia proteamaculans]
VKIVFAEQSWADYLYWQQTDKKMLKRVDELIREIQRSPMAGIGKPEPLKHNLSGFWSRRIDTEHRLVYQVTDDSLLIASC
CYHY

Nucleotide

• Length: 255 bp

>T142972 NZ_CP060914:c4589123-4588773 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9358.61 Da
• Isoelectric Point: 4.6258

>AT142972 WP_153858555.1 NZ_CP045913:2286581-2286832 [Serratia proteamaculans]
MKTLSFSEARQNFASVMNETFDDKAPILITRQKGTACVIMSLEEYESLEETAYLLRSPSNARHLMDSITELKSGRGLEKD
LAE

Nucleotide

• Length: 252 bp

>AT142972 NZ_CP060914:c4589368-4589117 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA