Detailed information of TA system TA142909

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1691183..1691367
• Replicon: chromosome
• Accession: NZ_CP045866
• Organism: Staphylococcus aureus strain CFSAN007894

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: AB466_RS08555
• Protein ID: WP_000482652.1
• Coordinates: 1691260..1691367 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1691183..1691243 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB466_RS08540	1686638..1686805	-	168	Protein_1648	hypothetical protein	-
AB466_RS08545	1687036..1688769	-	1734	WP_000486487.1	ABC transporter ATP-binding protein/permease	-
AB466_RS08550	1688794..1690557	-	1764	WP_001064825.1	ABC transporter ATP-binding protein/permease	-
-	1691183..1691243	+	61	-	-	Antitoxin
AB466_RS08555	1691260..1691367	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
AB466_RS08560	1691501..1691887	-	387	WP_000779360.1	flippase GtxA	-
AB466_RS08565	1692155..1693297	+	1143	WP_001176863.1	glycerate kinase	-
AB466_RS08570	1693357..1694016	+	660	WP_000831298.1	membrane protein	-
AB466_RS08575	1694198..1695409	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
AB466_RS08580	1695532..1696005	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T142909 WP_000482652.1 NZ_CP045866:c1691367-1691260 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T142909 NZ_CP060902:326830-327060 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT142909 NZ_CP045866:1691183-1691243 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin