Detailed information of TA system TA142908

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1665688..1666205
• Replicon: chromosome
• Accession: NZ_CP045866
• Organism: Staphylococcus aureus strain CFSAN007894

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3A3ATA4
• Locus tag: AB466_RS08420
• Protein ID: WP_000113265.1
• Coordinates: 1665688..1665954 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: AB466_RS08425
• Protein ID: WP_000584499.1
• Coordinates: 1665954..1666205 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB466_RS08390	1661116..1661652	-	537	WP_000169317.1	GNAT family N-acetyltransferase	-
AB466_RS08395	1661886..1662710	-	825	WP_000572038.1	formate/nitrite transporter family protein	-
AB466_RS08400	1662927..1663109	-	183	WP_000230292.1	hypothetical protein	-
AB466_RS08405	1663193..1663660	-	468	WP_000153347.1	SRPBCC domain-containing protein	-
AB466_RS08410	1663846..1665393	-	1548	WP_000727772.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
AB466_RS08415	1665582..1665653	-	72	Protein_1623	hypothetical protein	-
AB466_RS08420	1665688..1665954	-	267	WP_000113265.1	Txe/YoeB family addiction module toxin	Toxin
AB466_RS08425	1665954..1666205	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AB466_RS08430	1666370..1666471	-	102	Protein_1626	hypothetical protein	-
AB466_RS08435	1666478..1667077	-	600	WP_000162810.1	DsbA family protein	-
AB466_RS08440	1667096..1667458	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
AB466_RS08445	1667713..1668963	+	1251	WP_001012225.1	FemA/FemB family glycyltransferase FmhA	-
AB466_RS08450	1669060..1669791	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
AB466_RS08455	1669788..1670507	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.96 Da
• Isoelectric Point: 10.0573

>T142908 WP_000113265.1 NZ_CP045866:c1665954-1665688 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T142908 NZ_CP060899:c4518849-4518538 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT142908 WP_000584499.1 NZ_CP045866:c1666205-1665954 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT142908 NZ_CP060899:c4518537-4518247 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Structures

Toxin

• PDB: 7BWF

Antitoxin

• AlphaFold DB: T1YB60