Detailed information of TA system TA142906

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1406116..1406332
• Replicon: chromosome
• Accession: NZ_CP045866
• Organism: Staphylococcus aureus strain CFSAN007894

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: AB466_RS07065
• Protein ID: WP_001802298.1
• Coordinates: 1406228..1406332 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1406116..1406171 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB466_RS07045	1402322..1402987	-	666	WP_001024095.1	SDR family oxidoreductase	-
AB466_RS07050	1403139..1403459	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
AB466_RS07055	1403461..1404438	+	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
AB466_RS07060	1404704..1405795	+	1092	WP_000495669.1	hypothetical protein	-
-	1406116..1406171	+	56	-	-	Antitoxin
AB466_RS07065	1406228..1406332	-	105	WP_001802298.1	hypothetical protein	Toxin
AB466_RS07070	1407012..1407170	+	159	WP_001792784.1	hypothetical protein	-
AB466_RS07075	1407828..1408685	-	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
AB466_RS07080	1408753..1409535	-	783	WP_000908182.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T142906 WP_001802298.1 NZ_CP045866:c1406332-1406228 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T142906 NZ_CP060899:c4145298-4144948 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT142906 NZ_CP045866:1406116-1406171 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin